ArticleProceedings of the National Academy of Sciences of the United States of America2006
Ribosomal tethering and clustering as mechanisms for translation initiation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed.
- 40S ribosomal subunits scan mRNA for the start codon by one-dimensional diffusion.RNA (New York, N.Y.) · 2025Article
- The regulatory landscape of 5' UTRs in translational control during zebrafish embryogenesis.Developmental cell · 2025Article
- The regulatory landscape of 5' UTRs in translational control during zebrafish embryogenesis.bioRxiv : the preprint server for biology · 2023Article
- Precise genome editing across kingdoms of life using retron-derived DNA.Nature chemical biology · 2022Article
- Small Open Reading Frames, How to Find Them and Determine Their Function.Frontiers in genetics · 2021Review
- Unusual dicistronic expression from closely spaced initiation codons in an umbravirus subgenomic RNA.Nucleic acids research · 2018Article
- Exploring the Role of AUG Triplets in Human Cap-Independent Translation Enhancing Elements.Biochemistry · 2018Article
- Article
- A researcher's guide to the galaxy of IRESs.Cellular and molecular life sciences : CMLS · 2017Review
- RAN translation-What makes it run?Brain research · 2016Review
- Death of a dogma: eukaryotic mRNAs can code for more than one protein.Nucleic acids research · 2016Review
- Challenging the Roles of NSP3 and Untranslated Regions in Rotavirus mRNA Translation.PloS one · 2016Article
- The effect of heterogeneous Transcription Start Sites (TSS) on the translatome: implications for the mammalian cellular phenotype.BMC genomics · 2015Article
- Translation initiation mediated by RNA looping.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Exploring Internal Ribosome Entry Sites as Therapeutic Targets.Frontiers in oncology · 2015Review
- A critical analysis of codon optimization in human therapeutics.Trends in molecular medicine · 2014Review
- Optimization of mRNA design for protein expression in the crustacean Daphnia magna.Molecular genetics and genomics : MGG · 2014Article
- IRES-mediated translation of the pro-apoptotic Bcl2 family member PUMA.Translation (Austin, Tex.) · 2013Article
- Physical evidence supporting a ribosomal shunting mechanism of translation initiation for BACE1 mRNA.Translation (Austin, Tex.) · 2013Article
- Secondary RNA structure and nucleotide specificity contribute to internal initiation mediated by the human tau 5' leader.RNA biology · 2012Article
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Authors and funding
3 authors.
Funding
Abstract
Eukaryotic mRNAs often recruit ribosomal subunits some distance upstream of the initiation codon; however, the mechanisms by which they reach the initiation codon remain to be fully elucidated. Although scanning is a widely accepted model, evidence for alternative mechanisms has accumulated. We previously suggested that this process may involve tethering of ribosomal complexes to the mRNA, in which the intervening mRNA is bypassed, or clustering, in which the initiation codon is reached by dynamic binding and release of ribosomal subunits at internal sites. The present studies tested the feasibility of these ideas by using model mRNAs and revealed that translation efficiency varied with the distance between the site of ribosomal recruitment and the initiation codon. The present studies also showed that translation could initiate efficiently at AUG codons located upstream of an internal site. These observations are consistent with ribosomal tethering at the cap structure and clustering at internal sites.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.