ArticleProceedings of the National Academy of Sciences of the United States of America2006
Src-like adaptor protein (SLAP) regulates B cell receptor levels in a c-Cbl-dependent manner.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 43 citations in OpenAlex.
- Slap restricts oncogenic Src-family kinase signaling to maintain colonic epithelial homeostasis.eLife · 2026Article
- SLAP controls mTORC2 integrity via UBE3C-mediated non-degradative mLST8 ubiquitination to suppress colorectal tumorigenesis.Cell death and differentiation · 2026Article
- Overexpression of SLAP2 inhibits triple-negative breast cancer progression by promoting macrophage M1-type polarization.Scientific reports · 2024Article
- Sleuthing biochemical evidence to elucidate unassigned electron density in a CBL-SLAP2 crystal complex.Acta crystallographica. Section F, Structural biology communications · 2021Article
- SLAP Is a Negative Regulator of FcεRI Receptor-Mediated Signaling and Allergic Response.Frontiers in immunology · 2019Article
- Genetics and Pathogenesis of Diffuse Large B-Cell Lymphoma.The New England journal of medicine · 2018Article
- Role of SRC-like adaptor protein (SLAP) in immune and malignant cell signaling.Cellular and molecular life sciences : CMLS · 2015Review
- The Emerging and Diverse Roles of Src-Like Adaptor Proteins in Health and Disease.Mediators of inflammation · 2015Review
- SLAP/SLAP2 prevent excessive platelet (hem)ITAM signaling in thrombosis and ischemic stroke in mice.Blood · 2015Article
- SLAP deficiency decreases dsDNA autoantibody production.Clinical immunology (Orlando, Fla.) · 2014Article
- Activation of EphA receptors mediates the recruitment of the adaptor protein Slap, contributing to the downregulation of N-methyl-D-aspartate receptors.Molecular and cellular biology · 2013Article
- SLAP deficiency increases TCR avidity leading to altered repertoire and negative selection of cognate antigen-specific CD8+ T cells.Immunologic research · 2013Article
- The discovery of a reciprocal relationship between tyrosine-kinase signaling and cullin neddylation.PloS one · 2013Article
- Src-Like adaptor protein (SLAP) binds to the receptor tyrosine kinase Flt3 and modulates receptor stability and downstream signaling.PloS one · 2012Article
- SLAP deficiency enhances number and function of regulatory T cells preventing chronic autoimmune arthritis in SKG mice.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Src-like adaptor protein regulates osteoclast generation and survival.Journal of cellular biochemistry · 2010Article
- Src-like adaptor protein (SLAP) is upregulated in antigen-stimulated mast cells and acts as a negative regulator.Molecular immunology · 2009Article
- Mechanism of upregulation of the inhibitory regulator, src-like adaptor protein (SLAP), by glucocorticoids in mast cells.Molecular immunology · 2009Article
- Ins (endocytosis) and outs (exocytosis) of GLUT4 trafficking.Current opinion in cell biology · 2007Review
- On-bead screening of combinatorial libraries: reduction of nonspecific binding by decreasing surface ligand density.Journal of combinatorial chemistryArticle
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
Abstract
Src-like adaptor protein (SLAP) and c-Cbl recently have been shown to cooperate in regulating T cell receptor (TCR) levels in developing T cells. SLAP also is expressed in developing B cells, and its deficiency leads to alterations in B cell receptor (BCR) levels and B cell development. Hence, we hypothesized that SLAP and c-Cbl may cooperate during B cell development to regulate BCR levels. In mice deficient in both SLAP and c-Cbl, we found that B cell development is altered, suggesting that they function through intersecting pathways. To study the mechanism by which SLAP and c-Cbl alter BCR levels, we coexpressed them in a mature mouse B cell line (Bal-17). First we determined that SLAP associates with proximal components of the BCR complex after stimulation and internalization. Coexpression of SLAP and c-Cbl in Bal-17 led to decreased surface and total BCR levels. This decrease in BCR levels depended on intact Src homology 2 (SH2) and C-terminal domains of SLAP. In addition, a mutation in the SH2 domain of SLAP blocked its colocalization with c-Cbl and the BCR complex, whereas deletion of the C terminus did not affect its localization. Last, coexpression of SLAP and c-Cbl altered BCR complex recycling. This alteration in BCR complex recycling depended on enzymatically active c-Cbl and Src family kinases, as well as the intact SH2 and C-terminal domains of SLAP. These data suggest that SLAP has a conserved function in B and T cells by adapting c-Cbl to the antigen-receptor complex and targeting it for degradation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.