ArticleBioorganic & medicinal chemistry letters2007
Trifunctional norrisolide probes for the study of Golgi vesiculation.
Article in Bioorganic & medicinal chemistry letters, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 13 citations in OpenAlex.
- Golgi-modifying properties of macfarlandin E and the synthesis and evaluation of its 2,7-dioxabicyclo[3.2.1]octan-3-one core.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Chemical biology studies on norrisolide.Bioorganic & medicinal chemistry · 2010Article
- Marinopyrrole A target elucidation by acyl dye transfer.Journal of the American Chemical Society · 2009Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Inspired by the effect of norrisolide on the Golgi complex, we synthesized norrisolide probes that contain: the perhydroindane core of the parent natural product for Golgi localization, a crosslinking unit (aryl azide or epoxide) for covalent binding to the target, and a tag (biotin or iodine) for subsequent target purification. We found that biotin-containing probes 14, 20 and 24 induced inefficient Golgi vesiculation. However, the iodinated probe 25 induced extensive and irreversible Golgi fragmentation. This probe can be used for the isolation of the cellular target of norrisolide.
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Registered trials
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