ArticleSchizophrenia research2007
The burden of depressive symptoms in the long-term treatment of patients with schizophrenia.
Article in Schizophrenia research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers, 9 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
105 citing papers in PubMed, 9 syntheses or guidelines pooled it, 288 citations in OpenAlex.
- The prevalence and influencing factors of psychotic-like experiences in children and adolescents: a meta-analysis and systematic review.European child & adolescent psychiatry · 2026Pooled it
- Efficacy of adjunctive antidepressants in treating negative symptoms of schizophrenia: a systematic review and network meta-analysis.Psychological medicine · 2025Pooled it
- How do lipids influence risk of violence, self-harm and suicidality in people with psychosis? A systematic review.The Australian and New Zealand journal of psychiatry · 2022Pooled it
- Humour-based interventions for people with schizophrenia.The Cochrane database of systematic reviews · 2021Pooled it
- Antidepressive Effect of Antipsychotics in the Treatment of Schizophrenia: Meta-Regression Analysis of Randomized Placebo-Controlled Trials.The international journal of neuropsychopharmacology · 2021Pooled it
- Comorbid Major Depressive Disorder in Schizophrenia: A Systematic Review and Meta-Analysis.Schizophrenia bulletin · 2021Pooled it
- Emotional Dysregulation in Children and Adolescents With Psychiatric Disorders. A Narrative Review.Frontiers in psychiatry · 2021Pooled it
- Determinants of Physical Health Self-Management Behaviours in Adults With Serious Mental Illness: A Systematic Review.Frontiers in psychiatry · 2021Pooled it
- The Role of Demoralization and Hopelessness in Suicide Risk in Schizophrenia: A Review of the Literature.Medicina (Kaunas, Lithuania) · 2019Pooled it
- Randomised active controlled trial examining effects of aerobic exercise, cognitive and music interventions on depression, balance and mobility in schizophrenia.Scientific reports · 2025Trial
- The Psychopathology and Neuroanatomical Markers of Depression in Early Psychosis.Schizophrenia bulletin · 2021Trial
- A potential role for adjunctive omega-3 polyunsaturated fatty acids for depression and anxiety symptoms in recent onset psychosis: Results from a 16 week randomized placebo-controlled trial for participants concurrently treated with risperidone.Schizophrenia research · 2019Trial
- Lurasidone for the treatment of depressive symptoms in schizophrenia: analysis of 4 pooled, 6-week, placebo-controlled studies.CNS spectrums · 2015Trial
- Disrupted hierarchical functional brain organization in affective and psychotic disorders: insights from functional brain gradients.Translational psychiatry · 2026Article
- Glutathione deficiency in the early postnatal developmental period as a neurodevelopmental animal model of schizophrenia.Pharmacological reports : PR · 2026Review
- Identification of Shared Genetic Variants and Haplotypes Associated With Schizophrenia and Depression.Brain and behavior · 2026Article
- Post-Psychotic Depression: A Comprehensive Narrative Review.Diseases (Basel, Switzerland) · 2026Review
- Working memory and its neural characteristics in male schizophrenia patients with or without a history of violent behavior: an exploratory fNIRS study.BMC psychiatry · 2025Article
- The role of affective states in computational psychiatry.The international journal of neuropsychopharmacology · 2025Review
- AI-based prediction of depression symptomatology in first-episode psychosis patients: insights from the EUFEST and RAISE-ETP clinical trials.Psychological medicine · 2025Article
45 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo prospectively measure the link between depressive symptoms and functional outcomes in the long-term treatment of people with schizophrenia.
methodsData were drawn from a large, multi-site, 3-year, prospective, naturalistic, observational study, in which subjects with schizophrenia were assessed at enrollment and at 12-month intervals thereafter. Individuals who were "Depressed" (defined as a total score > or =16 on the Montgomery-Asberg Depression Rating Scale) at enrollment were compared to those "Non-depressed" on functional outcomes, using self-report measures, clinicians' ratings, and information from medical records. Statistical analyses included Generalized Estimation Equation and mixed regression analyses adjusted for individual characteristics. Longitudinal group comparisons across the 3-year study were augmented with a cross-sectional group comparison at enrollment.
resultsAt enrollment, 39.4% (877/2228) of the participants were deemed Depressed. Across the 3-year study, the depressed cohort was significantly more likely than the Non-depressed to use relapse-related mental health services (emergency psychiatric services, sessions with psychiatrists); to be a safety concern (violent, arrested, victimized, suicidal); to have greater substance-related problems; and to report poorer life satisfaction, quality of life, mental functioning, family relationships, and medication adherence. Furthermore, changes in depressed status were associated with changes in functional outcomes.
conclusionsPeople with schizophrenia and concurrent depressive symptoms have poorer long-term functional outcomes compared to the Non-depressed. Their poorer quality of life, greater use of mental health services, and higher risk of involvement with law enforcement agencies underscore a need for special treatment interventions. Treatment of the non-psychotic dimensions of schizophrenia is a critical part of recovery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.