ArticleBrain research2007
Injured Fluoro-Jade-positive hippocampal neurons contain high levels of zinc after traumatic brain injury.
Article in Brain research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 57 citations in OpenAlex.
- Lithium mitigates hippocampal tau pathology in a rodent model of traumatic brain injury.Acta neuropathologica communications · 2025Article
- What Are the Functions of Zinc in the Nervous System?Neurology · 2023Article
- Imbalance of Essential Metals in Traumatic Brain Injury and Its Possible Link with Disorders of Consciousness.International journal of molecular sciences · 2023Review
- Neuro-Inflammation Modulation and Post-Traumatic Brain Injury Lesions: From Bench to Bed-Side.International journal of molecular sciences · 2022Review
- Zinc in the Brain: Friend or Foe?International journal of molecular sciences · 2020Review
- Zinc and Traumatic Brain Injury: From Chelation to Supplementation.Medical sciences (Basel, Switzerland) · 2020Review
- The Influence of Heavy Metals and Trace Elements on Comatose Patients with Severe Traumatic Brain Injury in the First Week of Admission.Journal of toxicology · 2018Article
- Metabolic fate of glucose in rats with traumatic brain injury and pyruvate or glucose treatments: A NMR spectroscopy study.Neurochemistry international · 2017Article
- Vitamins and nutrients as primary treatments in experimental brain injury: Clinical implications for nutraceutical therapies.Brain research · 2016Review
- Does Short-Term Dietary Omega-3 Fatty Acid Supplementation Influence Brain Hippocampus Gene Expression of Zinc Transporter-3?International journal of molecular sciences · 2015Article
- Long-lasting suppression of acoustic startle response after mild traumatic brain injury.Journal of neurotrauma · 2015Article
- Hippocampal neuronal metal ion imbalance related oxidative stress in a rat model of chronic aluminum exposure and neuroprotection of meloxicam.Behavioral and brain functions : BBF · 2014Article
- Effects of antiepileptic drugs on antioxidant and oxidant molecular pathways: focus on trace elements.Cellular and molecular neurobiology · 2013Review
- Rapid accumulation of endogenous tau oligomers in a rat model of traumatic brain injury: possible link between traumatic brain injury and sporadic tauopathies.The Journal of biological chemistry · 2013Article
- Effects of trauma, hemorrhage and resuscitation in aged rats.Brain research · 2013Article
- Article
- Improving treatments and outcomes: an emerging role for zinc in traumatic brain injury.Nutrition reviews · 2012Review
- Fluorophilia: fluorophore-containing compounds adhere non-specifically to injured neurons.Brain research · 2012Article
- Ion channels and zinc: mechanisms of neurotoxicity and neurodegeneration.Journal of toxicology · 2012Article
- Lateral fluid percussion injury of the brain induces CCL20 inflammatory chemokine expression in rats.Journal of neuroinflammation · 2011Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Hippocampal damage contributes to cognitive dysfunction after traumatic brain injury (TBI). We previously showed that Fluoro-Jade, a fluorescent stain that labels injured, degenerating brain neurons, quantifies the extent of hippocampal injury after experimental fluid percussion TBI in rats. Coincidentally, we observed that injured neurons in the rat hippocampus also stained with Newport Green, a fluorescent dye specific for free ionic zinc. Here, we show that, regardless of injury severity or therapeutic intervention, the post-TBI population of injured neurons in rat hippocampal subfields CA1, CA3 and dentate gyrus is indistinguishable, both in numbers and anatomical distribution, from the population of neurons containing high levels of zinc. Treatment with lamotrigine, which inhibits presynaptic release of glutamate and presumably zinc that is co-localized with glutamate, reduced numbers of Fluoro-Jade-positive and Newport Green-positive neurons equally as did treatment with nicardipine, which blocks voltage-gated calcium channels through which zinc enters neurons. To confirm using molecular techniques that Fluoro-Jade and Newport Green-positive neurons are equivalent populations, we isolated total RNA from 25 Fluoro-Jade-positive and 25 Newport Green-positive pyramidal neurons obtained by laser capture microdissection (LCM) from the CA3 subfield, linearly amplified the mRNA and used quantitative ribonuclease protection analysis to demonstrate similar expression of mRNA for selected TBI-induced genes. Our data suggest that therapeutic interventions aimed at reducing neurotoxic zinc levels after TBI may reduce hippocampal neuronal injury.
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Registered trials
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