ArticleCell division2006
The centrosome and cell proliferation.
Article in Cell division, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- The DNA replication machinery transmits dual signals to prevent unscheduled licensing and execution of centrosome duplication.Nature communications · 2025Article
- Extra centrosomes delay DNA damage-driven tumorigenesis.Science advances · 2024Article
- Polyploid Giant Cancer Cells, a Hallmark of Oncoviruses and a New Therapeutic Challenge.Frontiers in oncology · 2020Review
- Expression of centrosomal protein 55 in glioma tissue and the influence on glioma cell functions.Translational cancer research · 2019Article
- Inhibition of polo-like kinase 4 (PLK4): a new therapeutic option for rhabdoid tumors and pediatric medulloblastoma.Oncotarget · 2017Article
- Low expression of centrosomal protein 78 (CEP78) is associated with poor prognosis of colorectal cancer patients.Chinese journal of cancer · 2016Article
- CEP55 contributes to human gastric carcinoma by regulating cell proliferation.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Vacuolar protein sorting 4B, an ATPase protein positively regulates the progression of NSCLC via promoting cell division.Molecular and cellular biochemistry · 2013Article
- Critical role of tyrosine 79 in the fluorescence resonance energy transfer and terbium(III)-dependent self-assembly of ciliate Euplotes octocarinatus centrin.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2010Article
- Human ESCRT-III and VPS4 proteins are required for centrosome and spindle maintenance.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Centrioles: active players or passengers during mitosis?Cellular and molecular life sciences : CMLS · 2010Review
- The c-Myc target glycoprotein1balpha links cytokinesis failure to oncogenic signal transduction pathways in cultured human cells.PloS one · 2010Article
- When 2+2=5: the origins and fates of aneuploid and tetraploid cells.Biochimica et biophysica acta · 2008Review
- Nedd1 expression as a marker of dynamic centrosomal localization during mouse embryonic development.Histochemistry and cell biology · 2008Article
- A novel Crumbs3 isoform regulates cell division and ciliogenesis via importin beta interactions.The Journal of cell biology · 2007Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Centrosomes are frequently amplified in cancer cells. Increased numbers of centrosomes can give rise to multipolar spindles in mitosis, and thereby lead to the formation of aneuploid daughter cells. However, whether centrosome amplification is a cause or a consequence of cancer is unclear. In contrast, loss of a functional centrosome has been shown to lead to cell cycle arrest. In this review, the potential mechanisms underlying centrosome amplification and centrosome-dependent cell cycle regulation are discussed.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.