ArticleCell proliferation2006
Possibility of selection of chondrogenic progenitor cells by telomere length in FGF-2-expanded mesenchymal stromal cells.
Article in Cell proliferation, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Comparative transcriptomic analysis of bovine mesenchymal stromal cells reveals tissue-source and species-specific differences.iScience · 2024Article
- Telomeres and Telomerase in the Control of Stem Cells.Biomedicines · 2022Review
- WNT/beta-catenin signalling interrupts a senescence-induction cascade in human mesenchymal stem cells that restricts their expansion.Cellular and molecular life sciences : CMLS · 2022Article
- Telomere shortening as a hallmark of stem cell senescence.Stem cell investigation · 2019Review
- Additive effect of bFGF and selenium on expansion and paracrine action of human amniotic fluid-derived mesenchymal stem cells.Stem cell research & therapy · 2018Article
- Comprehensive characterization of chorionic villi-derived mesenchymal stromal cells from human placenta.Stem cell research & therapy · 2018Article
- Environmental preconditioning rejuvenates adult stem cells' proliferation and chondrogenic potential.Biomaterials · 2017Review
- Fibroblast Growth Factor Ligand Dependent Proliferation and Chondrogenic Differentiation of Synovium-Derived Stem Cells and Concomitant Adaptation of Wnt/Mitogen-Activated Protein Kinase Signals.Tissue engineering. Part A · 2016Article
- Challenges in identifying the best source of stem cells for cardiac regeneration therapy.Stem cell research & therapy · 2015Review
- Optimization of pre-transplantation conditions to enhance the efficacy of mesenchymal stem cells.International journal of biological sciences · 2015Review
- Article
- Upregulation of Adipogenesis and Chondrogenesis in MSC Serum-Free Culture.Cell medicine · 2011Article
- Growth factor regulation of proliferation and survival of multipotential stromal cells.Stem cell research & therapy · 2010Review
- Monolayer cell expansion conditions affect the chondrogenic potential of adipose-derived stem cells.Biotechnology and bioengineering · 2008Article
- Telomere and telomerase in stem cells.British journal of cancer · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Telomere length plays an important role in regulating the proliferative capacity of cells, and serves as a marker for cell cycle history and also for their remaining replicative potential. Mesenchymal stromal cells (MSC) are known to be a significant cell source for therapeutic intervention and tissue engineering. To investigate any possible limitations in the replicative potential and chondrogenic differentiation potential of fibroblast growth factor-2-expanded MSCs (FGF(+)MSC), these cells were differentiated at various population doublings (PDs), and telomere length and telomerase activity were measured before and after differentiation. FGF(+)MSC cultured at a relatively low density maintained proliferation capability past more than 80 PD and maintained chondrogenic differentiation potential up to at least 46 PD and long telomeres up to 105 PD, despite expressing low levels of telomerase activity. Interestingly, upon chondrogenic differentiation of these cells, telomeres showed a remarkable reduction in length. This shortening was more extensive when FGF(+)MSC of higher PD levels were differentiated. These findings suggest that telomere length may be a useful genetic marker for chondrogenic progenitor cells.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.