ArticleThe Biochemical journal2007
Importin alpha1 is involved in the nuclear localization of Zac1 and the induction of p21WAF1/CIP1 by Zac1.
Article in The Biochemical journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 38 citations in OpenAlex.
- KPNA2 knockdown suppresses gastric cancer progression through modulation of the β-catenin/EMT signaling axis, inducing cell cycle arrest, apoptosis, and reduced metastatic capacity.Journal of molecular histology · 2026Article
- Tick Importin-α Is Implicated in the Interactome and Regulome of the Cofactor Subolesin.Pathogens (Basel, Switzerland) · 2021Article
- Differential Cytotoxicity Mechanisms of Copper Complexed with Disulfiram in Oral Cancer Cells.International journal of molecular sciences · 2021Article
- Mechanisms of Cisplatin in Combination with Repurposed Drugs against Human Endometrial Carcinoma Cells.Life (Basel, Switzerland) · 2021Article
- Integrative bioinformatics analysis of KPNA2 in six major human cancers.Open medicine (Warsaw, Poland) · 2021Article
- Article
- Metformin causes cancer cell death through downregulation of p53-dependent differentiated embryo chondrocyte 1.Journal of biomedical science · 2018Article
- Article
- Zac1 regulates IL-11 expression in osteoarthritis.Oncotarget · 2018Article
- Article
- Functional Analysis of VDR Gene Mutation R343H in A Child with Vitamin D-Resistant Rickets with Alopecia.Scientific reports · 2017Article
- Cell surface localization of importin α1/KPNA2 affects cancer cell proliferation by regulating FGF1 signalling.Scientific reports · 2016Article
- Characterization of a new mouse p53 variant: loss-of-function and gain-of-function.Journal of biomedical science · 2014Article
- Genetic and epigenetic mutations of tumor suppressive genes in sporadic pituitary adenoma.Molecular and cellular endocrinology · 2014Review
- KPNA2 promotes cell proliferation and tumorigenicity in epithelial ovarian carcinoma through upregulation of c-Myc and downregulation of FOXO3a.Cell death & disease · 2013Article
- Grail as a molecular determinant for the functions of the tumor suppressor p53 in tumorigenesis.Cell death and differentiation · 2013Article
- The functional role of the novel biomarker karyopherin α 2 (KPNA2) in cancer.Cancer letters · 2013Review
- Nuclear retention of importin α coordinates cell fate through changes in gene expression.The EMBO journal · 2012Article
- Functional and structural basis of the nuclear localization signal in the ZIC3 zinc finger domain.Human molecular genetics · 2008Article
- Different Isoforms of HPV-16 E7 Protein are Present in Cytoplasm and Nucleus.The open virology journal · 2008Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Zac1, a novel seven-zinc-finger transcription factor, preferentially binds GC-rich DNA elements and has intrinsic transactivation activity. To date, the NLS (nuclear localization signal) of Zac1 has not been empirically determined. We generated a series of EGFP (enhanced green fluorescence protein)-tagged deletion mutants of Zac1 and examined their subcellular localization, from which we defined two NLSs within the DNA-binding (or zinc-finger) domain. Fusion proteins consisting of the two EGFP-tagged zinc-finger clusters (zinc finger motifs 1-3 and 4-7) were located exclusively in the nucleus, demonstrating that each of the zinc-finger clusters is sufficient for nuclear localization. Physical interactions between these two zinc-finger clusters and importin alpha1 were demonstrated using an in vitro glutathione S-transferase pull-down assay. Finally, our results indicate that the association of Zac1 with importin alpha1 is also involved in regulating the transactivation activity of Zac1 on the p21WAF1/CIP1 gene and protein expression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.