ArticleEuropean journal of immunology2006
NF-kappa B binds to the immunoglobulin S gamma 3 region in vivo during class switch recombination.
Article in European journal of immunology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 16 citations in OpenAlex.
- NF-κB/RelA signaling required for CD40-induced humoral immunity depends on specific NEMO lysine residues in mice.The EMBO journal · 2026Article
- The NFκB signaling system in the generation of B-cell subsets: from germinal center B cells to memory B cells and plasma cells.Frontiers in immunology · 2023Review
- Oocytes could rearrange immunoglobulin production to survive over adverse environmental stimuli.Frontiers in immunology · 2022Article
- 53BP1 Contributes toJournal of immunology (Baltimore, Md. : 1950) · 2017Article
- Article
- Impaired B cell development and function in the absence of IkappaBNS.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Aging impairs murine B cell differentiation and function in primary and secondary lymphoid tissues.Aging and disease · 2011Article
- Dynamic changes in binding of immunoglobulin heavy chain 3' regulatory region to protein factors during class switching.The Journal of biological chemistry · 2011Article
- Roles of the NF-kappaB pathway in lymphocyte development and function.Cold Spring Harbor perspectives in biology · 2010Review
- Protein phosphatase 2A (PP2A) is increased in old murine B cells and mediates p38 MAPK/tristetraprolin dephosphorylation and E47 mRNA instability.Mechanisms of ageing and development · 2010Article
- NF-kappaB p50 plays distinct roles in the establishment and control of murine gammaherpesvirus 68 latency.Journal of virology · 2009Article
- Binding of LBP-1a to specific immunoglobulin switch regions in vivo correlates with specific repression of class switch recombination.European journal of immunology · 2009Article
- Sgamma3 switch sequences function in place of endogenous Sgamma1 to mediate antibody class switching.The Journal of experimental medicine · 2008Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Ig class switch recombination (CSR) is dependent upon the expression of activation-induced deaminase and targeted to specific isotypes by germ-line transcript expression and isotype-specific factors. NF-kappaB plays critical roles in multiple aspects of B cell biology and has been implicated in the mechanism of CSR by in vitro binding assays and altered S/S junctions derived from NF-kappaB p50-deficient mice. However, the pleiotropic contributions of NF-kappaB to gene expression in B cells has made discerning a direct role for NF-kappaB in CSR difficult. We now observe that binding of NF-kappaB components p50 and p65 is detected on Sgamma3 in vivo following lipopolysaccharide (LPS) activation and repressed by LPS + IL-4, suggesting a direct role for this factor in CSR. In vivo footprinting confirms occupancy of a previously defined NF-kappaB recognition site in Sgamma3 with the same temporal kinetics as found in the chromatin immunoprecipitation analysis. Binding of NF-kappaB components p50 and p65 was also detected on Sgamma1 following B cell activation. H3 histone hyper acetylation at Sgamma1 is strongly correlated with NF-kappaB binding, suggesting that NF-kappaB mediates chromatin remodeling in the Sgamma3 and Sgamma1 region.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.