ReviewInternational journal of colorectal disease2007
The role of chemotherapy in microsatellite unstable (MSI-H) colorectal cancer.
Review in International journal of colorectal disease, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Systematic review and meta-analysis of ovarian cancers: estimation of microsatellite-high frequency and characterization of mismatch repair deficient tumor histology.Clinical cancer research : an official journal of the American Association for Cancer Research · 2008Pooled it
- Structure-Activity Relationship Study of (ACS pharmacology & translational science · 2024Article
- Immune checkpoint inhibitors for the treatment of MSI-H/MMR-D colorectal cancer and a perspective on resistance mechanisms.British journal of cancer · 2019Review
- Outcomes of Chemotherapy for Microsatellite Instable-High Metastatic Colorectal Cancers.JCO precision oncology · 2018Article
- Microsatellite instability in colorectal cancer.EXCLI journal · 2018Review
- Systemic Analysis of Predictive Biomarkers for Recurrence in Colorectal Cancer Patients Treated with Curative Surgery.Digestive diseases and sciences · 2015Article
- Colorectal cancer intrinsic subtypes predict chemotherapy benefit, deficient mismatch repair and epithelial-to-mesenchymal transition.International journal of cancer · 2014Article
- CHFR silencing or microsatellite instability is associated with increased antitumor activity of docetaxel or gemcitabine in colorectal cancer.International journal of cancer · 2014Article
- A robust genomic signature for the detection of colorectal cancer patients with microsatellite instability phenotype and high mutation frequency.The Journal of pathology · 2012Article
- Microsatellite instability in colorectal cancer.Radiology and oncology · 2011Article
- 5-Fluorouracil response in a large panel of colorectal cancer cell lines is associated with mismatch repair deficiency.British journal of cancer · 2010Article
- A review of the most promising biomarkers in colorectal cancer: one step closer to targeted therapy.The oncologist · 2010Review
- Mucinous histology predicts for poor response rate and overall survival of patients with colorectal cancer and treated with first-line oxaliplatin- and/or irinotecan-based chemotherapy.British journal of cancer · 2009Article
- Screening for germline mutations of MLH1, MSH2, MSH6 and PMS2 genes in Slovenian colorectal cancer patients: implications for a population specific detection strategy of Lynch syndrome.Familial cancer · 2009Article
- Adenoma-infiltrating lymphocytes (AILs) are a potential marker of hereditary nonpolyposis colorectal cancer.The American journal of surgical pathology · 2008Article
- Emerging molecular biology of pancreatic cancer.Gastrointestinal cancer research : GCR · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionHigh-frequency microsatellite instability (MSI-H) is an alternate pathway of colorectal carcinogenesis, which accounts for 15% of all sporadic colorectal cancers. These tumours arise from mutations in the DNA mismatch repair system and thus have different responses to chemotherapeutic agents compared to microsatellite stable (MSS) cancers.
objectiveThis review aims to summarise the available literature on the responses to chemotherapy in MSI-H colorectal cancer (CRC). RESULTS AND DISCUSSION: 5 Fluorouracil (5FU) is commonly used as a chemotherapeutic agent in colon cancer and in vitro evidence shows reduced response to 5FU in MSI-H CRC. The clinical evidence is conflicting but favours a reduced response to 5FU in MSI-H CRC. Several newer agents such as COX-2 inhibitors and irinotecan are also reviewed.
conclusionAvailable evidence suggests that MSI-H CRC have different behaviour patterns and response to chemotherapy compared with MSS CRC.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.