ArticleNucleic acids research2007
The HIV positive selection mutation database.
Article in Nucleic acids research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- DRESIS 2.0: the comprehensive landscape of drug resistance information.Nucleic acids research · 2026Article
- Review
- DRESIS: the first comprehensive landscape of drug resistance information.Nucleic acids research · 2023Article
- Mapping the drivers of within-host pathogen evolution using massive data sets.Nature communications · 2019Article
- Observational
- HIV-1 drug resistance mutations emerging on darunavir therapy in PI-naive and -experienced patients in the UK.The Journal of antimicrobial chemotherapy · 2016Article
- Unraveling the web of viroinformatics: computational tools and databases in virus research.Journal of virology · 2015Review
- Genetic Consequences of Antiviral Therapy on HIV-1.Computational and mathematical methods in medicine · 2015Review
- Natural polymorphisms and unusual mutations in HIV-1 protease with potential antiretroviral resistance: a bioinformatic analysis.BMC bioinformatics · 2014Article
- Identification of the critical sites of NNRTI-resistance in reverse transcriptase of HIV-1 CRF_BC strains.PloS one · 2014Article
- A coordinated proteomic approach for identifying proteins that interact with the E. coli ribosomal protein S12.Journal of proteome research · 2013Article
- Computational analysis of HIV-1 protease protein binding pockets.Journal of chemical information and modeling · 2010Article
- JCoDA: a tool for detecting evolutionary selection.BMC bioinformatics · 2010Article
- A phylogenetic and Markov model approach for the reconstruction of mutational pathways of drug resistance.Bioinformatics (Oxford, England) · 2009Article
- Identification of HCV protease inhibitor resistance mutations by selection pressure-based method.Nucleic acids research · 2009Article
- ORION-VIRCAT: a tool for mapping ICTV and NCBI taxonomies.Database : the journal of biological databases and curation · 2009Article
- Evidence of a novel RNA secondary structure in the coding region of HIV-1 pol gene.RNA (New York, N.Y.) · 2008Article
- Positive selection on HIV accessory proteins and the analysis of molecular adaptation after interspecies transmission.Journal of molecular evolution · 2008Article
- Distinguishing functional amino acid covariation from background linkage disequilibrium in HIV protease and reverse transcriptase.PloS one · 2007Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The HIV positive selection mutation database is a large-scale database available at http://www.bioinformatics.ucla.edu/HIV/ that provides detailed selection pressure maps of HIV protease and reverse transcriptase, both of which are molecular targets of antiretroviral therapy. This database makes available for the first time a very large HIV sequence dataset (sequences from approximately 50 000 clinical AIDS samples, generously contributed by Specialty Laboratories, Inc.), which makes possible high-resolution selection pressure mapping. It provides information about not only the selection pressure on individual sites but also how selection pressure at one site is affected by mutations on other sites. It also includes datasets from other public databases, namely the Stanford HIV database [S. Y. Rhee, M. J. Gonzales, R. Kantor, B. J. Betts, J. Ravela and R. W. Shafer (2003) Nucleic Acids Res., 31, 298-303]. Comparison between these datasets in the database enables cross-validation with independent datasets and also specific evaluation of the effect of drug treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.