Evidence map›Paper›PMID 17108287›Full record

ArticleClinical and vaccine immunology : CVI2007

Naturally occurring anti-Escherichia coli protein antibodies in the sera of healthy humans cause analytical interference in a recombinant nucleocapsid protein-based enzyme-linked immunosorbent assay for serodiagnosis of severe acute respiratory syndrome.

Chi Wai Yip, Chung Chau Hon, Fanya Zeng, Ken Y C Chow, Kwok Hung Chan, Joseph S M Peiris, Frederick C C Leung

Open access · diamondAbstract read
In one paragraph

Article in Clinical and vaccine immunology : CVI, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Highly effective serodiagnosis for Chagas' disease.Clinical and vaccine immunology : CVI · 2010
    Article
  8. The SARS-CoV nucleocapsid protein: a protein with multifarious activities.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2008
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Chi Wai YipDepartment of Zoology, Kadoorie Biological Science Building, The University of Hong Kong, Pokfulam Road, Hong Kong, SAR, China.
Chung Chau Hon
Fanya Zeng
Ken Y C Chow
Kwok Hung Chan
Joseph S M Peiris
Frederick C C Leung
University of Hong Kong · HK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We reported the analytical interference of anti-Escherichia coli protein (EP) antibodies in human sera and residual EP in a recombinant nucleocapsid protein-based enzyme-linked immunosorbent assay as a possible source of false positives in severe acute respiratory syndrome serodiagnosis. The rate of false positives was significantly reduced by adding mouse anti-EP antiserum in the blocking step.

Indexed as

Antibodies, BacterialCoronavirus Nucleocapsid ProteinsEnzyme-Linked Immunosorbent AssayEscherichia coli ProteinsHumansNucleocapsid ProteinsSerologic TestsSevere Acute Respiratory SyndromeSevere acute respiratory syndrome-related coronavirusAntibodies, BacterialCoronavirus Nucleocapsid ProteinsEscherichia coli ProteinsNucleocapsid Proteins

Identifiers

PMID17108287
PMCPMC1797702
OpenAlexW2147625191

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.