ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2006
Stable rhodopsin/arrestin complex leads to retinal degeneration in a transgenic mouse model of autosomal dominant retinitis pigmentosa.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 70 citations in OpenAlex.
- NECAP antagonizes light-induced Rhodopsin-1 internalization to promote photoreceptor homeostasis.bioRxiv : the preprint server for biology · 2026Article
- Aggregation of the Constitutively Active K296E Rhodopsin Mutant Contributes to Retinal Degeneration.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Synchronized Photoactivation of T4K Rhodopsin Causes a Chromophore-Dependent Retinal Degeneration That Is Moderated by Interaction with Phototransduction Cascade Components.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Molecular basis of retinal remodeling in a zebrafish model of retinitis pigmentosa.Cellular and molecular life sciences : CMLS · 2023Article
- Arrestin Facilitates Rhodopsin DephosphorylationThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Drosophila fabp is required for light-dependent Rhodopsin-1 clearance and photoreceptor survival.PLoS genetics · 2021Article
- Polyphenols and Visual Health: Potential Effects on Degenerative Retinal Diseases.Molecules (Basel, Switzerland) · 2021Review
- Dark noise and retinal degeneration from D190N-rhodopsin.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- ER complex proteins are required for rhodopsin biosynthesis and photoreceptor survival in Drosophila and mice.Cell death and differentiation · 2020Article
- Human eye conditions: insights from the fly eye.Human genetics · 2019Review
- The molecular and cellular basis of rhodopsin retinitis pigmentosa reveals potential strategies for therapy.Progress in retinal and eye research · 2018Review
- Light-Induced Thiol Oxidation of Recoverin Affects Rhodopsin Desensitization.Frontiers in molecular neuroscience · 2018Article
- Biochemical Measurements of Free Opsin in Macular Degeneration Eyes: Examining the 11-Transactions of the American Ophthalmological Society · 2017Review
- Two pathways of rod photoreceptor cell death induced by elevated cGMP.Human molecular genetics · 2017Article
- Separation of photoreceptor cell compartments in mouse retina for protein analysis.Molecular neurodegeneration · 2017Article
- Effect of Rhodopsin Phosphorylation on Dark Adaptation in Mouse Rods.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Light regulates the ciliary protein transport and outer segment disc renewal of mammalian photoreceptors.Developmental cell · 2015Article
- Induction of the unfolded protein response by constitutive G-protein signaling in rod photoreceptor cells.The Journal of biological chemistry · 2014Article
- Photoactivation-induced instability of rhodopsin mutants T4K and T17M in rod outer segments underlies retinal degeneration in X. laevis transgenic models of retinitis pigmentosa.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Hsp90 inhibition protects against inherited retinal degeneration.Human molecular genetics · 2014Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Over 100 rhodopsin mutation alleles have been associated with autosomal dominant retinitis pigmentosa (ADRP). These mutations appear to cause photoreceptor cell death through diverse molecular mechanisms. We show that K296E, a rhodopsin mutation associated with ADRP, forms a stable complex with arrestin that is toxic to mouse rod photoreceptors. This cell death pathway appears to be conserved from flies to mammals. A genetics approach to eliminate arrestin unmasked the constitutive activity of K296E and caused photoreceptor cell death through a transducin-dependent mechanism that is similar to light damage. Expressing K296E in the arrestin/transducin double knock-out background prevented transducin signaling and led to substantially improved retinal morphology but did not fully prevent cell death caused by K296E. The adverse effect of K296E in the arrestin/transducin knock-out background can be mimicked by constant exposure to low light. Furthermore, we found that arrestin binding causes K296E to mislocalize to the wrong cellular compartment. Accumulation of stable rhodopsin/arrestin complex in the inner segment may be an important mechanism for triggering the cell death pathway in the mammalian photoreceptor cell.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.