ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2006
Cranial visceral afferent pathways through the nucleus of the solitary tract to caudal ventrolateral medulla or paraventricular hypothalamus: target-specific synaptic reliability and convergence patterns.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers.
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Who cites it
98 citing papers in PubMed, 145 citations in OpenAlex.
- Vagal sensing of altered gut microbiota links to externalizing behaviors.Gut microbes · 2026Article
- Bursting Parameters Alter Excitatory Postsynaptic Currents in Nucleus Tractus Solitarius Neurons: Implications for Clinical Vagus Nerve Stimulation.Journal of neurochemistry · 2026Article
- Microglia alter autonomic nucleus neuronal activation after peripheral cytokine challenge.American journal of physiology. Cell physiology · 2026Article
- Characterization of NTS-to-VTA projection neurons reveals higher-order synaptic organization and distinct responsiveness to cholecystokinin.The Journal of physiology · 2025Article
- Brainstem Noradrenergic Neuronal Populations: Dual Effects on Regulating GnRH and LH Secretion.Endocrinology · 2025Review
- Noradrenaline Regulation of Brain-Body Communication.Advances in experimental medicine and biology · 2025Review
- Percutaneous Electrical Nerve Field Stimulation in Children and Adolescents With Functional Dyspepsia-Integrating a Behavioral Intervention.Neuromodulation : journal of the International Neuromodulation Society · 2024Article
- Circadian regulation of glutamate release pathways shapes synaptic throughput in the brainstem nucleus of the solitary tract (NTS).The Journal of physiology · 2023Article
- Analysis of the distribution of vagal afferent projections from different peripheral organs to the nucleus of the solitary tract in rats.The Journal of comparative neurology · 2022Article
- Regulation of Rostral Nucleus of the Solitary Tract Responses to Afferent Input by A-type K+ Current.Neuroscience · 2022Article
- Vagus nerve stimulation activates nucleus of solitary tract neurons via supramedullary pathways.The Journal of physiology · 2021Article
- Dedicated C-fiber vagal sensory afferent pathways to the paraventricular nucleus of the hypothalamus.Brain research · 2021Article
- An Inhibitory Circuit From Brainstem to GnRH Neurons in Male Mice: A New Role for the RFRP Receptor.Endocrinology · 2021Article
- Evidence of intermediate reticular formation involvement in swallow pattern generation, recorded optically in the neonate rat sagittally sectioned hindbrain.Journal of neurophysiology · 2021Article
- Central afferents to the nucleus of the solitary tract in rats and mice.The Journal of comparative neurology · 2020Article
- Leptin Sensitizes NTS Neurons to Vagal Input by Increasing Postsynaptic NMDA Receptor Currents.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Carotid bodies contribute to sympathoexcitation induced by acute salt overload.Experimental physiology · 2019Article
- Lung-injury depresses glutamatergic synaptic transmission in the nucleus tractus solitarii via discrete age-dependent mechanisms in neonatal rats.Brain, behavior, and immunity · 2018Article
- Estradiol and the control of feeding behavior.Steroids · 2018Review
- Role of the Carotid Bodies in the Hypertensive and Natriuretic Responses to NaCl Load in Conscious Rats.Frontiers in physiology · 2018Article
38 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Cranial visceral afferents activate central pathways that mediate systemic homeostatic processes. Afferent information arrives in the brainstem nucleus of the solitary tract (NTS) and is relayed to other CNS sites for integration into autonomic responses and complex behaviors. Little is known about the organization or nature of processing within NTS. We injected fluorescent retrograde tracers into two nuclei to identify neurons that project to sites involved in autonomic regulation: the caudal ventrolateral medulla (CVLM) or paraventricular nucleus of the hypothalamus (PVN). We found distinct differences in synaptic connections and performance in the afferent path through NTS to these neurons. Anatomical studies using confocal and electron microscopy found prominent, primary afferent synapses directly on somata and dendrites of CVLM-projecting NTS neurons identifying them as second-order neurons. In brainstem slices, afferent activation evoked large, constant latency EPSCs in CVLM-projecting NTS neurons that were consistent with the precise timing and rare failures of monosynaptic contacts on second-order neurons. In contrast, most PVN-projecting NTS neurons lacked direct afferent input and responded to afferent stimuli with highly variable, intermittently failing synaptic responses, indicating polysynaptic pathways to higher-order neurons. The afferent-evoked EPSCs in most PVN-projecting NTS neurons were smaller and unreliable but also often included multiple, convergent polysynaptic responses not observed in CVLM-projecting neurons. A few PVN-projecting NTS neurons had monosynaptic EPSC characteristics. Together, we found that cranial visceral afferent pathways are structured distinctly within NTS depending on the projection target. Such, intra-NTS pathway architecture will substantially impact performance of autonomic or neuroendocrine reflex arcs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.