ArticleEnvironmental health perspectives2006
Molecular epidemiologic evidence for diabetogenic effects of dioxin exposure in U.S. Air force veterans of the Vietnam war.
Article in Environmental health perspectives, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 89 citations in OpenAlex.
- U.S. Blue Water Navy Veterans of the Vietnam War: Comparisons from the Vietnam Era Health Retrospective Observational Study (VE-HEROeS).Journal of military and veterans' health · 2023Article
- Spatiotemporal patterns of polychlorinated dibenzo-p-dioxins and dibenzofurans and dioxin-like polychlorinated biphenyls in foodstuffs in air quality regions in Taiwan.Journal of food and drug analysis · 2020Article
- Increased AHR Transcripts Correlate With Pro-inflammatory T-Helper Lymphocytes Polarization in Both Metabolically Healthy Obesity and Type 2 Diabetic Patients.Frontiers in immunology · 2020Article
- Long-Term Effects of Chemical Warfare on Post-traumatic Stress Disorder, Depression, and Chronic Medical Conditions in Veterans.Community mental health journal · 2019Article
- Transgenic Overexpression of Aryl Hydrocarbon Receptor Repressor (AhRR) and AhR-Mediated Induction of CYP1A1, Cytokines, and Acute Toxicity.Environmental health perspectives · 2016Article
- Role of Aryl Hydrocarbon Receptor in Circadian Clock Disruption and Metabolic Dysfunction.Environmental health insights · 2016Review
- Health status of male steel workers at an electric arc furnace (EAF) in Trentino, Italy.Journal of occupational medicine and toxicology (London, England) · 2016Article
- Aryl hydrocarbon receptor deficiency protects mice from diet-induced adiposity and metabolic disorders through increased energy expenditure.International journal of obesity (2005) · 2015Article
- Persistent organic pollutants and biomarkers of diabetes risk in a cohort of Great Lakes sport caught fish consumers.Environmental research · 2015Article
- Impaired glucose and lipid metabolism in ageing aryl hydrocarbon receptor deficient mice.EXCLI journal · 2015Article
- Chlorinated persistent organic pollutants, obesity, and type 2 diabetes.Endocrine reviews · 2014Review
- Association of dioxin and other persistent organic pollutants (POPs) with diabetes: epidemiological evidence and new mechanisms of beta cell dysfunction.International journal of molecular sciences · 2014Review
- Diabetes and its comorbidities--where East meets West.Nature reviews. Endocrinology · 2013Review
- Diabetes, metabolic syndrome, and obesity in relation to serum dioxin concentrations: the Seveso women's health study.Environmental health perspectives · 2013Article
- Polychlorinated Biphenyls, Glycaemia and Diabetes in a Population Living in a Highly Polychlorinated Biphenyls-Polluted Area in Northern Italy: a Cross-sectional and Cohort Study.Journal of public health research · 2013Article
- IL-22 mRNA expression in blood samples as a useful biomarker for assessing the adverse health effects of PCBs on allergic children.International journal of environmental research and public health · 2012Article
- Polychlorinated biphenyl exposure, diabetes and endogenous hormones: a cross-sectional study in men previously employed at a capacitor manufacturing plant.Environmental health : a global access science source · 2012Article
- Aryl hydrocarbon receptor deficiency enhances insulin sensitivity and reduces PPAR-α pathway activity in mice.Environmental health perspectives · 2011Article
- The paradox of progress: environmental disruption of metabolism and the diabetes epidemic.Diabetes · 2011Article
- Increase in metabolic syndrome-related hospitalizations in relation to environmental sources of persistent organic pollutants.International journal of environmental research and public health · 2011Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundOne of the outcomes positively associated with dioxin exposure in humans is type 2 diabetes.
objectivesThis study was conducted in order to find the molecular biological evidence for the diabetogenic action of dioxin in adipose samples from Vietnam veterans.
methodsWe obtained 313 adipose tissue samples both from Vietnam veterans who were exposed to dioxin (Operation Ranch Hand) and from comparison veterans who served in Southeast Asia with no record of dioxin exposure. We conducted quantitative reverse-transcribed polymerase chain reaction studies on selected marker mRNAs from these samples.
resultsWe found the most sensitive and reliable molecular indicator of dioxin-induced diabetes to be the ratio of mRNA of glucose transporter 4 (GLUT4) and nuclear transcription factor kappa B (NFkappaB), a marker of inflammation. This ratio showed significant correlations to serum dioxin residues and to fasting glucose among those in the Ranch Hand group and, surprisingly, even in the comparison group, who have low levels of dioxin comparable to the general public. Such a correlation in the comparison group was particularly significant among those with known risk factors such as obesity and family history of diabetes.
conclusionsThese results show that the GLUT4:NFkappaB ratio is a reliable marker for the diabetogenic action of dioxin, particularly at very low exposure levels that are not much higher than those found in the general public, implying a need to address current exposure levels.
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