ArticleEnvironmental health perspectives2006
The importance of hormesis to public health.
Article in Environmental health perspectives, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed.
- Sulforaphane improves the bronchoprotective response in asthmatics through Nrf2-mediated gene pathways.Respiratory research · 2015Trial
- Article
- PLGA-Based Curcumin Delivery System: An Interesting Therapeutic Approach in the Treatment of Alzheimer's Disease.Current neuropharmacology · 2022Review
- Thyroid Stem Cells But Not Differentiated Thyrocytes Are Sensitive to Slightly Increased Concentrations of Heavy Metals.Frontiers in endocrinology · 2021Article
- The Glyoxalase System-New Insights into an Ancient Metabolism.Antioxidants (Basel, Switzerland) · 2020Review
- Connecting Western and Eastern Medicine from an Energy Perspective.International journal of molecular sciences · 2019Review
- A web-based tool for designing experimental studies to detect hormesis and estimate the threshold dose.Statistical papers (Berlin, Germany) · 2018Article
- Mild heat stress induces hormetic effects in protecting the primary culture of mouse prefrontal cerebrocortical neurons from neuropathological alterations.IBRO reports · 2018Article
- R(+)-Thioctic Acid Effects on Oxidative Stress and Peripheral Neuropathy in Type II Diabetic Patients: Preliminary Results by Electron Paramagnetic Resonance and Electroneurography.Oxidative medicine and cellular longevity · 2018Article
- The dose response principle from philosophy to modern toxicology: The impact of ancient philosophy and medicine in modern toxicology science.Toxicology reports · 2018Review
- Intake of Boron, Cadmium, and Molybdenum enhances rat thyroid cell transformation.Journal of experimental & clinical cancer research : CR · 2017Article
- Non-monotonic dose responses in studies of endocrine disrupting chemicals: bisphenol a as a case study.Dose-response : a publication of International Hormesis Society · 2014Article
- Study of the hormetic effect of disinfectants chlorhexidine, povidone iodine and benzalkonium chloride.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2014Article
- Hormesis, cell death, and regenerative medicine for neurode-generative diseases.Dose-response : a publication of International Hormesis Society · 2013Article
- Shifting the paradigm in radiation safety.Dose-response : a publication of International Hormesis Society · 2012Article
- Effects of polyphenols on brain ageing and Alzheimer's disease: focus on mitochondria.Molecular neurobiology · 2012Review
- Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses.Endocrine reviews · 2012Review
- Optimal experimental design strategies for detecting hormesis.Risk analysis : an official publication of the Society for Risk Analysis · 2011Article
- Radiation and cancer risk: a continuing challenge for epidemiologists.Environmental health : a global access science source · 2011Review
- Cellular stress responses, the hormesis paradigm, and vitagenes: novel targets for therapeutic intervention in neurodegenerative disorders.Antioxidants & redox signaling · 2010Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHormesis is a specific type of nonmonotonic dose response whose occurrence has been documented across a broad range of biological models, diverse types of exposure, and a variety of outcomes. The effects that occur at various points along this curve can be interpreted as beneficial or detrimental, depending on the biological or ecologic context in which they occur.
objectiveBecause hormesis appears to be a relatively common phenomenon that has not yet been incorporated into regulatory practice, the objective of this commentary is to explore some of its more obvious public health and risk assessment implications, with particular reference to issues raised recently within this journal by other authors. DISCUSSION: Hormesis appears to be more common than dose-response curves that are currently used in the risk assessment process [e.g., linear no-threshold (LNT)]. Although a number of mechanisms have been identified that explain many hormetic dose-response relationships, better understanding of this phenomenon will likely lead to different strategies not only for the prevention and treatment of disease but also for the promotion of improved public health as it relates to both specific and more holistic health outcomes.
conclusionsWe believe that ignoring hormesis is poor policy because it ignores knowledge that could be used to improve public health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.