ArticleVirology journal2006
Serendipitous identification of natural intergenotypic recombinants of hepatitis C in Ireland.
Article in Virology journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 67 citations in OpenAlex.
- Characterization of hepatitis C virus genotypes by direct sequencing of HCV 5'UTR region of isolates from Saudi Arabia.PloS one · 2014Trial
- Mixed Infections Unravel Novel HCV Inter-Genotypic Recombinant Forms within the Conserved IRES Region.Viruses · 2024Article
- First identification of a recombinant form of hepatitis C virus in Austrian patients by full-genome next generation sequencing.PloS one · 2017Article
- Heads or Tails: Genotyping of Hepatitis C Virus Concerning the 2k/1b Circulating Recombinant Form.International journal of molecular sciences · 2016Article
- High incidence of the hepatitis C virus recombinant 2k/1b in Georgia: Recommendations for testing and treatment.Hepatology research : the official journal of the Japan Society of Hepatology · 2015Article
- Hepatitis C virus genetic variability and evolution.World journal of hepatology · 2015Review
- Whole genome pyrosequencing of rare hepatitis C virus genotypes enhances subtype classification and identification of naturally occurring drug resistance variants.The Journal of infectious diseases · 2013Article
- Origin and evolution of the unique hepatitis C virus circulating recombinant form 2k/1b.Journal of virology · 2012Article
- Recombination in hepatitis C virus: identification of four novel naturally occurring inter-subtype recombinants.PloS one · 2012Article
- Naturally occurring genotype 2b/1a hepatitis C virus in the United States.Virology journal · 2011Article
- Recombination in hepatitis C virus.Viruses · 2011Review
- Stability of yellow fever virus under recombinatory pressure as compared with chikungunya virus.PloS one · 2011Article
- Near-full genome characterisation of two natural intergenotypic 2k/1b recombinant hepatitis C virus isolates.Advances in virology · 2011Article
- Comparison of the Mechanisms of Drug Resistance among HIV, Hepatitis B, and Hepatitis C.Viruses · 2010Article
- Correlation of the 5'untranslated region (5'UTR) and non-structural 5B (NS5B) nucleotide sequences in hepatitis C virus subtyping.International journal of molecular epidemiology and genetics · 2010Article
- Evidence of recombination in Hepatitis C Virus populations infecting a hemophiliac patient.Virology journal · 2009Article
- Naturally occurring hepatitis C virus subgenomic deletion mutants replicate efficiently in Huh-7 cells and are trans-packaged in vitro to generate infectious defective particles.Journal of virology · 2009Article
- Structural and functional characterization of nonstructural protein 2 for its role in hepatitis C virus assembly.The Journal of biological chemistry · 2008Article
- Article
- Correlation between pre-treatment quasispecies complexity and treatment outcome in chronic HCV genotype 3a.Virology journal · 2008Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecombination between hepatitis C single stranded RNA viruses is a rare event. Natural viable intragenotypic and intergenotypic recombinants between 1b-1a, 1a-1c and 2k-1b, 2i-6p, respectively, have been reported. Diagnostically recombinants represent an intriguing challenge. Hepatitis C genotype is defined by interrogation of the sequence composition of the 5' untranslated region [5'UTR]. Occasionally, ambiguous specimens require further investigation of the genome, usually by interrogation of the NS5B region. The original purpose of this study was to confirm the existence of a suspected mixed genotype infection of genotypes 2 and 4 by clonal analysis at the NS5B region of the genome in two specimens from two separate individuals. This initial identification of genotype was based on analysis of the 5'UTR of the genome by reverse line probe hybridisation [RLPH].
resultsThe original diagnosis of a mixed genotype infection was not confirmed by clonal analysis of the NS5B region of the genome. The phylogenetic analysis indicated that both specimens were natural intergenotypic recombinant forms of HCV. The recombination was between genotypes 2k and 1b for both specimens. The recombination break point was identified as occurring within the NS2 region of the genome.
conclusionThe viral recombinants identified here resemble the recombinant form originally identified in Russia. The RLPH pattern observed in this study may be a signature indicative of this particular type of intergenotype recombinant of hepatitis C meriting clonal analysis of NS2.
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