ReviewBrain pathology (Zurich, Switzerland)2006
Pathophysiological mechanisms for actions of the neurotrophins.
Review in Brain pathology (Zurich, Switzerland), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 52 citations in OpenAlex.
- Review
- Urine Nerve Growth Factor May Not Be Useful as a Biomarker of Overactive Bladder in Patients with Pelvic Organ Prolapse.Journal of clinical medicine · 2022Article
- The Expression and Cellular Localisation of Neurotrophin and Neural Guidance Molecules in Peritoneal Ectopic Lesions.Molecular neurobiology · 2019Article
- Copper Binding Features of Tropomyosin-Receptor-Kinase-A Fragment: Clue for Neurotrophic Factors and Metals Link.International journal of molecular sciences · 2018Article
- [Research progress of P75 neurotrophin receptor and new idea of nonunion treatment].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2017Review
- Plasma Brain-Derived Neurotrophic Factor Levels in Newborn Infants with Neonatal Abstinence Syndrome.Frontiers in pediatrics · 2017Article
- Neurotrophic Activity of Cultured Cell Line U87 is Up-Regulated by Proline-Rich Polypeptide Complex and Its Constituent Nonapeptide.Cellular and molecular neurobiology · 2015Article
- Biomaterial Approaches to Enhancing Neurorestoration after Spinal Cord Injury: Strategies for Overcoming Inherent Biological Obstacles.BioMed research international · 2015Review
- Derailed intraneuronal signalling drives pathogenesis in sporadic and familial Alzheimer's disease.BioMed research international · 2014Review
- Fragment C of tetanus toxin: new insights into its neuronal signaling pathway.International journal of molecular sciences · 2012Review
- Tyrosine kinase B protein expression is reduced in the cerebellum of patients with bipolar disorder.Journal of affective disorders · 2011Article
- Long descending cervical propriospinal neurons differ from thoracic propriospinal neurons in response to low thoracic spinal injury.BMC neuroscience · 2010Article
- Ciliary neurotrophic factor cell-based delivery prevents synaptic impairment and improves memory in mouse models of Alzheimer's disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Effects of proNGF on neuronal viability, neurite growth and amyloid-beta metabolism.Neurotoxicity research · 2010Article
- Brain-derived neurotrophic factor in infants <32 weeks gestational age: correlation with antenatal factors and postnatal outcomes.Pediatric research · 2009Article
- The role of cholinergic and GABAergic medial septal/diagonal band cell populations in the emergence of diencephalic amnesia.Neuroscience · 2009Article
- Regulation of axonal regeneration following the central nervous system injury in adult mammalian.Neuroscience bulletin · 2008Review
- p75 neurotrophin receptor regulates agonist-induced pulmonary vasoconstriction.American journal of physiology. Heart and circulatory physiology · 2008Article
- Targeting of neurotrophic factors, their receptors, and signaling pathways in the developmental neurotoxicity of organophosphates in vivo and in vitro.Brain research bulletin · 2008Article
- Oligodendroglial cells and neurotrophins: a polyphonic cantata in major and minor.Journal of molecular neuroscience : MN · 2008Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Neurotrophins provide trophic and tropic support for different neuronal subpopulations in the developing and adult nervous systems. Expression of the neurotrophins and their receptors can be altered in several different disease or injury states that impact upon the functions in the central and peripheral nervous systems. The intracellular signals used by the neurotrophins are triggered by ligand binding to the cell surface Trk and p75NTR receptors. In general, signals emanating from Trk receptors support survival, growth and synaptic strengthening, while those emanating from p75NTR induce apoptosis, attenuate growth and weaken synaptic signaling. Mature neurotrophins are the preferred ligand for Trk proteins while p75NTR binds preferentially to the proneurotrophins and serves as a signaling component of the receptor complex for growth inhibitory molecules of central nervous system myelin [ie, myelin-associated glycoprotein (MAG), oligodendrocyte-myelin glycoprotein (OMgP) and Nogo]. The functional antagonism between Trk and p75NTR signaling may significantly impact the pathogenesis of human neurodevelopmental and neurodegenerative diseases and further complicate therapeutic uses of exogenous neurotrophins. The potential for each is discussed in this review.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.