ArticleWorld journal of gastroenterology2006
Antioxidants vitamin E and C attenuate hepatic fibrosis in biliary-obstructed rats.
Article in World journal of gastroenterology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 50 citations in OpenAlex.
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- Potential use of antioxidants for the treatment of chronic inflammatory diseases.Frontiers in pharmacology · 2024Review
- Potassium affects the association between dietary intake of vitamin C and NAFLD among adults in the United States.PloS one · 2024Article
- Dendropanoxide Alleviates Thioacetamide-induced Hepatic Fibrosis via Inhibition of ROS Production and Inflammation in BALB/International journal of biological sciences · 2023Article
- Therapeutic Potential of the Combination of Pentoxifylline and Vitamin-E in Inflammatory Bowel Disease: Inhibition of Intestinal Fibrosis.Journal of clinical medicine · 2022Article
- Er-Chen Decoction Alleviates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease in Rats through Remodeling Gut Microbiota and Regulating the Serum Metabolism.Evidence-based complementary and alternative medicine : eCAM · 2022Article
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- Antioxidant, Anti-Inflammatory and Anti-Apoptotic Activities of Nesfatin-1: A Review.Journal of inflammation research · 2020Review
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- Protective Effects of Peroxiredoxin 4 (PRDX4) on Cholestatic Liver Injury.International journal of molecular sciences · 2018Article
- Food components with antifibrotic activity and implications in prevention of liver disease.The Journal of nutritional biochemistry · 2018Review
- Possible Involvement of Nitric Oxide in Enhanced Liver Injury and Fibrogenesis during Cholestasis in Cytoglobin-deficient Mice.Scientific reports · 2017Article
- Nesfatin-1 alleviates extrahepatic cholestatic damage of liver in rats.Bosnian journal of basic medical sciences · 2016Article
- Vitamin A supplementation alleviates extrahepatic cholestasis liver injury through Nrf2 activation.Oxidative medicine and cellular longevity · 2014Article
- Image analysis tools for evaluation of microscopic views of immunohistochemically stained specimen in medical research-a review.Journal of medical systems · 2012Review
- Time course of collagen peak in bile duct-ligated rats.BMC gastroenterology · 2011Article
- Quercetin treatment ameliorates systemic oxidative stress in cirrhotic rats.ISRN gastroenterology · 2011Article
- The interstitial lymphatic peritoneal mesothelium axis in portal hypertensive ascites: when in danger, go back to the sea.International journal of inflammation · 2010Article
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate whether antioxidants vitamin E and C can retard development of hepatic fibrosis in the biliary-obstructed rats.
methodsFifty Wistar albino rats were randomly assigned to 5 groups (10 rats in each). Bile duct was ligated in 40 rats and they were treated as follows: group vitC, vitamin C 10 mg/kg sc daily; group vitE, vitamin E 15 mg/kg sc daily; group vitEC, both of the vitamins; bile duct-ligated (BDL, control) group, physiological saline sc. The fifth group was assigned to sham operation. At the end of fourth week, the rats were decapitated, and hepatic tissue biochemical collagen content and collagen surface area were measured. Hepatic tissue specimens were histopathologically evaluated according to Scheuer system. Serum hyaluronate levels were measured by ELISA method.
resultsDespite being higher than sham group, hepatic collagen level was significantly decreased in each of the vitC, vitE and vitEC groups (32.7 +/- 1.2, 33.8 +/- 2.9, 36.7 +/- 0.5 mug collagen/mg protein, respectively) compared to BDL (48.3 +/- 0.6 mg collagen/g protein) (P < 0.001 for each vitamin group). Each isolated vitamin C, isolated vitamin E and combined vitamin E/C supplementation prevented the increase in hepatic collagen surface density (7.0% +/- 1.1%, 6.2% +/- 1.7%, 12.3% +/- 2.0%, respectively) compared to BDL (17.4% +/- 5.6%) (P < 0.05 for each). The same beneficial effect of vitamin C, vitamin E and combined vitamin E/C treatment was also observed on the decrease of serum hyaluronate levels compared to BDL group (P < 0.001). The relative liver and spleen weights, serum transaminases, cholestatic enzymes, bilirubins and histopathological inflammation scores were not different between the antioxidant treatment groups and the control. However, fibrosis staging scores were obviously reduced only in the vitamin E/C combination group (vit EC: 2.4 +/- 0.8 vs BDL: 3.1 +/- 0.7; P < 0.05).
conclusionEach antioxidant vitamin E, vitamin C and their combination retard hepatic fibrosis in biliary-obstructed rats. Oxidative stress may play a role in the pathogenesis of hepatic fibrosis in secondary biliary cirrhosis.
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