ArticleWorld journal of gastroenterology2006
Hepatic lipid metabolism changes in short- and long-term prehepatic portal hypertensive rats.
Article in World journal of gastroenterology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 25 citations in OpenAlex.
- Metabolomics reveals altered metabolites in cirrhotic patients with severe portal hypertension in Tibetan population.Frontiers in medicine · 2024Article
- Embrionary way to create a fatty liver in portal hypertension.World journal of gastrointestinal pathophysiology · 2017Review
- Low-light-level therapy as a treatment for minimal hepatic encephalopathy: behavioural and brain assessment.Lasers in medical science · 2016Article
- Splanchnic-aortic inflammatory axis in experimental portal hypertension.World journal of gastroenterology · 2013Review
- A half century (1961-2011) of applying microsurgery to experimental liver research.World journal of hepatology · 2012Article
- Brain metabolism and spatial memory are affected by portal hypertension.Metabolic brain disease · 2012Article
- The interstitial lymphatic peritoneal mesothelium axis in portal hypertensive ascites: when in danger, go back to the sea.International journal of inflammation · 2010Article
- Chronic prehepatic portal hypertension in the rat: is it a type of metabolic inflammatory syndrome?Lipids in health and disease · 2008Article
- Inflammation: a way to understanding the evolution of portal hypertension.Theoretical biology & medical modelling · 2007Review
- The mast cell integrates the splanchnic and systemic inflammatory response in portal hypertension.Journal of translational medicine · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo verify the impairment of the hepatic lipid metabolism in prehepatic portal hypertension.
methodsThe concentrations of free fatty acids, diacylglycerol, triglycerides, and phospholipids were assayed by using D-[U-14C] glucose incorporation in the different lipid fractions and thin-layer chromatography and cholesterol was measured by spectrophotometry, in liver samples of Wistar rats with partial portal vein ligation at short- (1 mo) and long-term (1 year) (i.e. portal hypertensive rats) and the control rats.
resultsIn the portal hypertensive rats, liver phospholipid synthesis significantly decreased (7.42 +/- 0.50 vs 4.70 +/- 0.44 nCi/g protein; P < 0.01) and was associated with an increased synthesis of free fatty acids (2.08 +/- 0.14 vs 3.36 +/- 0.33 nCi/g protein; P < 0.05), diacylglycerol (1.93 +/- 0.2 vs 2.26 +/- 0.28 nCi/g protein), triglycerides (2.40 +/- 0.30 vs 4.49 +/- 0.15 nCi/g protein) and cholesterol (24.28 +/- 2.12 vs 57.66 +/- 3.26 mg/g protein; P < 0.01).
conclusionPrehepatic portal hypertension in rats impairs the liver lipid metabolism. This impairment consists in an increase in lipid deposits (triglycerides, diacylglycerol and cholesterol) in the liver, accompanied by a decrease in phospholipid synthesis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.