ArticleWorld journal of gastroenterology2006
Dexamethasone mediates protection against acute pancreatitis via upregulation of pancreatitis-associated proteins.
Article in World journal of gastroenterology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Efficacy of glucocorticoids in rodents of severe acute pancreatitis: a meta-analysis.International journal of clinical and experimental pathology · 2014Pooled it
- Clinical observation on the effect of dexamethasone and Chinese herbal decoction for purgation in severe acute pancreatitis patients.Chinese journal of integrative medicine · 2011Trial
- Obtusifolin ameliorates pancreatic tissue injury and inflammation by modulating the NFκB signaling.Journal of molecular histology · 2026Article
- Pancreatic Injury in Severe SARS-CoV-2 Infection: A Retrospective Study Across Three Pandemic Waves.Life (Basel, Switzerland) · 2025Article
- Association between Severe SARS-CoV-2 Infection and Severe Acute Pancreatitis in Pregnancy and Postpartum.Journal of clinical medicine · 2022Article
- ACVIM consensus statement on pancreatitis in cats.Journal of veterinary internal medicine · 2021Article
- Article
- Emodin alleviates severe acute pancreatitis-associated acute lung injury by decreasing pre-B-cell colony-enhancing factor expression and promoting polymorphonuclear neutrophil apoptosis.Molecular medicine reports · 2017Article
- Traditional Chinese medicine, Qing Ying Tang, ameliorates the severity of acute lung injury induced by severe acute pancreatitis in rats via the upregulation of aquaporin-1.Experimental and therapeutic medicine · 2014Article
- Effects of dexamethasone and Salvia miltiorrhiza on multiple organs in rats with severe acute pancreatitis.Journal of Zhejiang University. Science. B · 2012Article
- Acute pancreatitis in aging animals: loss of pancreatitis-associated protein protection?World journal of gastroenterology · 2012Article
- Study of dexamethasone, baicalin and octreotide on brain injury of rats with severe acute pancreatitis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2012Article
- Comparison of His and GST tagged versions of recombinant pancreatitis associated protein 2 in modulation of inflammatory responses.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2010Article
- Pancreatic regenerating protein I in chronic pancreatitis and aging: implications for new therapeutic approaches to diabetes.Pancreas · 2008Article
- Small-interference RNA gene knockdown of pancreatitis-associated proteins in rat acute pancreatitis.Pancreas · 2008Article
- Use of gene expression profiles in cells of peripheral blood to identify new molecular markers of acute pancreatitis.Archives of surgery (Chicago, Ill. : 1960) · 2008Article
- Dexamethasone mediates protection against acute pancreatitis via upregulation of pancreatitis-associated proteins.World journal of gastroenterology · 2006Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
aimTo examine the influence of dexamethasone on pancreatitis-associated protein (PAP) gene expression using both in vitro and in vivo models of acute pancreatitis and to study how PAP gene expression correlates with severity of pancreatitis.
methodsIn vitro, IL-6 stimulated pancreas acinar AR42J cells were cultured with increasing concentrations of dexamethasone and assayed for PAP expression (RT-PCR). In vivo, pancreatitis was induced in rats by retrograde injection of 40 g/L taurocholate into the pancreatic duct. Animals were pretreated with dexamethasone (2 mg/kg) daily or saline for 4 d. Pancreata and serum were harvested after 24 h and gene expression levels of PAP I, II and III were measured by RT-PCR. Severity of pancreatitis was based on serum amylase, pancreatic wet weight, and histopathological score.
resultsIn vitro, dexamethasone and IL-6 induced a marked transcription of PAP I, II and III genes in AR42J cells at 24 h (P < 0.05 for all comparisons). In vivo, pancreas mRNA levels of PAP I, II or III increased by 2.6-fold, 1.9-fold, and 1.3-fold respectively after dexamethasone treatment, compared with saline treated animals. Serum amylase levels and edema were significantly lower in the dexamethasone group compared with the saline group. Histopathologic evaluation revealed less inflammation and necrosis in pancreata obtained from dexamethasone treated animals (P < 0.05).
conclusionDexamethasone significantly decreases the severity of pancreatitis. The protective mechanism of dexamethasone may be via upregulating PAP gene expression during injury.
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