ArticleInternational journal of legal medicine2007
Y-STR analysis of degraded DNA using reduced-size amplicons.
Article in International journal of legal medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Recovery of male DNA acquired from carrion-feeding insects in a simulated sexual assault scenario.Journal of forensic sciences · 2026Article
- Sequence Variations of 31 Υ-Chromosomal Short Tandem Repeats Analyzed by Massively Parallel Sequencing in Three U.S. Population Groups and Korean Population.Journal of Korean medical science · 2022Article
- Efficacy of reduced-size short tandem repeat PCR analysis for degraded DNA samples.Genes & genomics · 2021Article
- Seventeen Y-chromosomal short tandem repeat haplotypes in seven groups of population living in Taiwan.International journal of legal medicine · 2010Article
- Investigative strategy for the forensic detection of sperm traces.Forensic science, medicine, and pathology · 2009Article
- Null allele sequence structure at the DYS448 locus and implications for profile interpretation.International journal of legal medicine · 2008Article
- Evaluation of miniY-STR multiplex PCR systems for extended 16 Y-STR loci.International journal of legal medicine · 2008Article
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Authors and funding
5 authors.
Funding
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Abstract
To increase the success rate of Y-STR genotyping for degraded DNA, we have developed two multiplex PCR sets for 21 Y-STR loci. Besides the 17 Y-STR loci of DYS19, DYS385, DYS389-I, DYS389-II, DYS390, DYS391, DYS392, DYS393, DYS437, DYS438, DYS439, DYS448, DYS456, DYS458, DYS635, and GATA H4.1 contained in a commercial Y-STR kit, AmpFlSTR Yfiler, the other four loci of DYS388, DYS446, DYS447, and DYS449 were also included in the multiplexes to increase the discrimination capacity. Among a total of 21 Y-STR loci, the primers for eight loci (DYS385, DYS390, DYS438, DYS446, DYS448, DYS449, and DYS635) were newly designed in the present study and nine loci (DYS385, DYS390, DYS391, DYS392, DYS438, DYS439, DYS448, and DYS635) have PCR amplicons smaller than those of the AmpFlSTR Yfiler kit. A sensitivity test using serially diluted standard 9948 male DNA showed that all the values of Y-STR loci in the Y-miniplexes are reliable at template concentrations as low as 30 pg. We compared the effectiveness of the two multiplexes with the AmpFlSTR Yfiler kit by using both enzymatically degraded DNA and 30 samples of 50-year-old skeletal remains. This comparison demonstrated that the new Y-miniplex sets can produce a better signal from degraded DNA than the AmpFlSTR Yfiler kit.
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