Evidence map›Paper›PMID 17106718›Full record

Trial reportEuropean journal of applied physiology2007

Isometric handgrip training improves local flow-mediated dilation in medicated hypertensives.

Cheri L McGowan, Adrienne Visocchi, Martha Faulkner, Robin Verduyn, Mark Rakobowchuk, Andrew S Levy, Neil McCartney, Maureen J MacDonald

Erratum issued Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of applied physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT04467879 (A Pivotal Study To Evaluate The Effectiveness of Isometric Handgrip Therapy In Prehypertensive And Hypertensive Patients), which is not on this map. Cited by 44 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04467879 naterminatednot on this mapstarted 2020, after this paper: background citation

A Pivotal Study To Evaluate The Effectiveness of Isometric Handgrip Therapy In Prehypertensive And Hypertensive Patients

TypeinterventionalSponsorZona Health, IncRan2020 to 2022Enrolled146ConditionsHypertension, SystolicArmsZona Plus Device, Control Device
3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 7 syntheses or guidelines pooled it.

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  11. Effects of dynamic, isometric and combined resistance training on blood pressure and its mechanisms in hypertensive men.Hypertension research : official journal of the Japanese Society of Hypertension · 2023
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4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

8 authors.

Cheri L McGowanDepartment of Kinesiology, McMaster University, 1280 Main Street West, Hamilton, ON, Canada.
Adrienne Visocchi
Martha Faulkner
Robin Verduyn
Mark Rakobowchuk
Andrew S Levy
Neil McCartney
Maureen J MacDonald

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bilateral isometric handgrip (IHG) training lowers resting arterial blood pressure (BP) in medicated hypertensives. Numerous mechanisms have been suggested, but have yet to be investigated. One such mechanism is that of improved systemic endothelial-dependent vasodilation. The purpose of this investigation was twofold: (1) to determine if bilateral IHG training had any beneficial effects on endothelial-dependent vasodilation, and (2) to see if improved systemic endothelial-dependent vasodilation was responsible for lowering BP. Sixteen participants performed four, 2 min IHG contractions at 30% of their maximal voluntary effort, using either a bilateral (n = 7) or a unilateral IHG protocol (n = 9), three times per week for 8 weeks. Brachial artery (BA) flow-mediated dilation (FMD, an index of endothelial-dependent vasodilation, measured in both arms) was assessed pre- and post-training. Following bilateral IHG training, BA FMD improved in both arms (normalized to peak shear rate 0.005 +/- 0.001 to 0.02 +/- 0.002 s(-1), P < 0.01). Following unilateral IHG training, BA FMD improved in the trained arm only (normalized 0.009 +/- 0.002 to 0.02 +/- 0.005 s(-1), P < 0.01). These findings suggest that although IHG training improves endothelial-dependent vasodilation, the improvements only occur locally in the trained limbs. This suggests that enhanced systemic endothelial-dependent vasodilation is not the mechanism responsible for the observed post-IHG training reductions in BP in medicated hypertensives.

Indexed as

Blood PressureExerciseHand StrengthIsometric ContractionVasodilationAgedAntihypertensive AgentsBlood Flow VelocityBrachial ArteryCanadaCohort StudiesEndothelium, VascularFemaleHumansHyperemiaHypertensionAntihypertensive AgentsLipids

Identifiers

PMID17106718

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.