SynthesisSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2007
Laetrile for cancer: a systematic review of the clinical evidence.
Synthesis in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.
- Laetrile treatment for cancer.The Cochrane database of systematic reviews · 2015Pooled it
- Cancer Chemotherapeutic Effect of Vernonia Amygdalina Delile on Glioblastoma Brain Cancer Cell.Asian Pacific journal of cancer prevention : APJCP · 2024Article
- Review
- Amygdalin: Toxicity, Anticancer Activity and Analytical Procedures for Its Determination in Plant Seeds.Molecules (Basel, Switzerland) · 2021Review
- Article
- Effects of the Gut microbiota on Amygdalin and its use as an anti-cancer therapy: Substantial review on the key components involved in altering dose efficacy and toxicity.Biochemistry and biophysics reports · 2018Review
- Natural products against cancer angiogenesis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Review
- Toxic phytochemicals and their potential risks for human cancer.Cancer prevention research (Philadelphia, Pa.) · 2015Review
- Article
- Amygdalin blocks bladder cancer cell growth in vitro by diminishing cyclin A and cdk2.PloS one · 2014Article
- Complementary or alternative medicine in cancer care-myths and realities.Nature reviews. Clinical oncology · 2013Review
- Herbal-drug interaction induced rhabdomyolysis in a liposarcoma patient receiving trabectedin.BMC complementary and alternative medicine · 2013Article
- Putative mechanisms of antitumor activity of cyano-substituted heteroaryles in HeLa cells.Investigational new drugs · 2012Article
- [Complementary medicine in oncology].Der Urologe. Ausg. A · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMany cancer patients treated with conventional therapies also try 'alternative' cancer treatments. Laetrile is one such 'alternative' that is claimed to be effective by many alternative therapists. Laetrile is also sometimes referred to as amygdalin, although the two are not the same.
objectiveThe aim of this review is to summarize all types of clinical data related to the effectiveness or safety of laetrile interventions as a treatment of any type of cancer. MATERIALS AND
methodsAll types of clinical studies containing original clinical data of laetrile interventions were included. We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE (from 1951), EMBASE (from 1980), Allied and Complementary Medicine (AMED), Scirus, CancerLit, Cumulative Index to Nursing and Allied Health (CINAHL; all from 1982), CAMbase (from 1998), the MetaRegister, the National Research Register, and our own files. For reports on the safety of laetrile, we also searched the Uppsala database. No language restrictions were imposed.
resultsThirty six reports met our inclusion criteria. No controlled clinical trials were found. Three articles were nonconsecutive case series, 2 were consecutive case series, 6 were best case series, and 25 were case reports. None of these publications proved the effectiveness of laetrile.
conclusionTherefore, the claim that laetrile has beneficial effects for cancer patients is not supported by sound clinical data.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.