ArticleRNA (New York, N.Y.)2007
Modular evolution and increase of functional complexity in replicating RNA molecules.
Article in RNA (New York, N.Y.), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Selection for Molecularly Complementary Modules (MCMs) Drives the Origins and Evolution of Pleiofunctional, Epistatic Interactomes (PEIs).Life (Basel, Switzerland) · 2026Review
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- Did organs precede organisms in the origin of life?microLife · 2024Article
- Self-empowerment of life through RNA networks, cells and viruses.F1000Research · 2023Review
- A scenario for the emergence of protoviroids in the RNA world and for their further evolution into viroids and viroid-like RNAs by modular recombinations and mutations.Virus evolution · 2022Review
- The hammerhead self-cleaving motif as a precursor to complex endonucleolytic ribozymes.RNA (New York, N.Y.) · 2021Article
- Possible Ancestral Functions of the Genetic and RNA Operational Precodes and the Origin of the Genetic System.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2021Article
- Social Networking of Quasi-Species Consortia drive Virolution via Persistence.AIMS microbiology · 2021Review
- On the emergence of structural complexity in RNA replicators.RNA (New York, N.Y.) · 2019Article
- Article
- Editorial: Genome Invading RNA Networks.Frontiers in microbiology · 2018Article
- Molecular trade-offs in RNA ligases affected the modular emergence of complex ribozymes at the origin of life.Royal Society open science · 2017Article
- Improving the odds: Influence of starting pools on in vitro selection outcomes.Methods (San Diego, Calif.) · 2016Review
- Reviving the RNA World: An Insight into the Appearance of RNA Methyltransferases.Frontiers in genetics · 2016Review
- Freeze-thaw cycles as drivers of complex ribozyme assembly.Nature chemistry · 2015Article
- Template directed replication supports the maintenance of the metabolically coupled replicator system.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2015Article
- Non-canonical 3'-5' extension of RNA with prebiotically plausible ribonucleoside 2',3'-cyclic phosphates.Journal of the American Chemical Society · 2014Article
- The RNA world hypothesis: the worst theory of the early evolution of life (except for all the others)(a).Biology direct · 2012Article
- The dawn of the RNA World: toward functional complexity through ligation of random RNA oligomers.RNA (New York, N.Y.) · 2009Article
- Evolution of complexity in RNA-like replicator systems.Biology direct · 2008Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
At early stages of biochemical evolution, the complexity of replicating molecules was limited by unavoidably high mutation rates. In an RNA world, prior to the appearance of cellular life, an increase in molecular length, and thus in functional complexity, could have been mediated by modular evolution. We describe here a scenario in which short, replicating RNA sequences are selected to perform a simple function. Molecular function is represented through the secondary structure corresponding to each sequence, and a given target secondary structure yields the optimal function in the environment where the population evolves. The combination of independently evolved populations may have facilitated the emergence of larger molecules able to perform more complex functions (including RNA replication) that could arise as a combination of simpler ones. We quantitatively show that modular evolution has relevant advantages with respect to the direct evolution of large functional molecules, among them the allowance of higher mutation rates, the shortening of evolutionary times, and the very possibility of finding complex structures that could not be otherwise directly selected.
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