ReviewPharmaceutical research2007
Molecular insights into the structure-function relationship of organic anion transporters OATs.
Review in Pharmaceutical research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed.
- Article
- Regulation of organic anion transporters: Role in physiology, pathophysiology, and drug elimination.Pharmacology & therapeutics · 2021Review
- The role of solute carrier (SLC) transporters in actinomycin D pharmacokinetics in paediatric cancer patients.European journal of clinical pharmacology · 2018Article
- Trafficking and other regulatory mechanisms for organic anion transporting polypeptides and organic anion transporters that modulate cellular drug and xenobiotic influx and that are dysregulated in disease.British journal of pharmacology · 2017Review
- Posttranslational Regulation of Organic Anion Transporters by Ubiquitination: Known and Novel.Medicinal research reviews · 2016Review
- Human oligopeptide transporter 2 (PEPT2) mediates cellular uptake of polymyxins.The Journal of antimicrobial chemotherapy · 2016Article
- Human organic anion transporting polypeptide 1A2 (OATP1A2) mediates cellular uptake of all-trans-retinol in human retinal pigmented epithelial cells.British journal of pharmacology · 2015Article
- The altered renal and hepatic expression of solute carrier transporters (SLCs) in type 1 diabetic mice.PloS one · 2015Article
- Probenecid as a sensitizer of bisphosphonate-mediated effects in breast cancer cells.Molecular cancer · 2014Article
- A genome wide study of genetic adaptation to high altitude in feral Andean Horses of the páramo.BMC evolutionary biology · 2013Article
- Primary porcine proximal tubular cells as an alternative to human primary renal cells in vitro: an initial characterization.BMC cell biology · 2013Article
- Structural characterization of 1,3-propanedithiols that feature carboxylic acids: Homologues of mercury chelating agents.Polyhedron · 2013Article
- Multispecific drug transporter Slc22a8 (Oat3) regulates multiple metabolic and signaling pathways.Drug metabolism and disposition: the biological fate of chemicals · 2013Article
- Glutaric aciduria type 1 metabolites impair the succinate transport from astrocytic to neuronal cells.The Journal of biological chemistry · 2011Article
- Glycosylation of the OCTN2 carnitine transporter: study of natural mutations identified in patients with primary carnitine deficiency.Biochimica et biophysica acta · 2011Article
- Pharmacogenomics of drug metabolizing enzymes and transporters: implications for cancer therapy.Pharmacogenomics and personalized medicine · 2011Article
- Interferon tau regulates PGF2alpha release from the ovine endometrial epithelial cells via activation of novel JAK/EGFR/ERK/EGR-1 pathways.Molecular endocrinology (Baltimore, Md.) · 2010Article
- Vitamin E status and metabolism in adult and aged aryl hydrocarbon receptor null mice.The Journal of nutritional biochemistry · 2010Article
- Regulation of human organic anion transporter 4 by protein kinase C and NHERF-1: altering the endocytosis of the transporter.Pharmaceutical research · 2010Article
- Dependence of multidrug resistance protein-mediated cyclic nucleotide efflux on the background sodium conductance.Molecular pharmacology · 2010Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The organic anion transporter (OAT) family encoded by SLC22A mediates the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of mammalian species. Several OATs have been identified: OAT1 (SLC22A6), OAT2 (SLC22A7), OAT3 (SLC22A8), OAT4 (SLC22A11), OAT5 (SLC22A19) OAT6 (SLC22A20) and URAT1 (SLC22A12). The expressions of these OATs have been detected in key organs such as kidney, liver, brain and placenta. OAT dysfunction in these organs may contribute to the renal, hepatic, neurological and fetal toxicity and diseases. In this review, we summarize, according to the work done by our laboratory as well as by others, the most updated molecular studies on these OAT members, especially on the aspect of their structure-function relationships. The functional roles of N-glycosylation, transmembrane domains and individual amino acids, cell surface assembly, as well as associating proteins will be discussed. In addition, we will show the recent analyses of coding region polymorphisms of OATs, which give us information on the genetic variants of OATs and their potential effects on OAT functions.
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