ArticleJournal of bioenergetics and biomembranes2006
H-prune-nm23-H1 protein complex and correlation to pathways in cancer metastasis.
Article in Journal of bioenergetics and biomembranes, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 33 citations in OpenAlex.
- Neuroimaging in PRUNE1 syndrome: a mini-review of the literature.Frontiers in neurology · 2023Review
- Neurodevelopmental disorder with microcephaly, hypotonia, and variable brain anomalies in a consanguineous Iranian family is associated with a homozygous start loss variant in the PRUNE1 gene.BMC medical genomics · 2022Article
- NMIHBA results from hypomorphic PRUNE1 variants that lack short-chain exopolyphosphatase activity.Human molecular genetics · 2021Article
- Functional Genomics of PRUNE1 in Neurodevelopmental Disorders (NDDs) Tied to Medulloblastoma (MB) and Other Tumors.Frontiers in oncology · 2021Review
- Inorganic polyphosphate in platelet rich plasma accelerates re-epithelializationRegenerative therapy · 2020Article
- A competitive cell-permeable peptide impairs Nme-1 (NDPK-A) and Prune-1 interaction: therapeutic applications in cancer.Laboratory investigation; a journal of technical methods and pathology · 2018Review
- Oncogenic Epstein-Barr virus recruits Nm23-H1 to regulate chromatin modifiers.Laboratory investigation; a journal of technical methods and pathology · 2018Review
- Transcriptional factor FOXO3 negatively regulates the expression of nm23-H1 in non-small cell lung cancer.Thoracic cancer · 2016Article
- Modulation of cytoskeletal dynamics by mammalian nucleoside diphosphate kinase (NDPK) proteins.Naunyn-Schmiedeberg's archives of pharmacology · 2015Review
- Regulation of the metastasis suppressor Nm23-H1 by tumor viruses.Naunyn-Schmiedeberg's archives of pharmacology · 2015Review
- Recruited metastasis suppressor NM23-H2 attenuates expression and activity of peroxisome proliferator-activated receptor δ (PPARδ) in human cholangiocarcinoma.Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver · 2015Article
- Nm23-h1 binds to gelsolin and inactivates its actin-severing capacity to promote tumor cell motility and metastasis.Cancer research · 2013Article
- Neuroblastoma tumorigenesis is regulated through the Nm23-H1/h-Prune C-terminal interaction.Scientific reports · 2013Article
- The Nm23-H1-h-Prune complex in cellular physiology: a 'tip of the iceberg' protein network perspective.Molecular and cellular biochemistry · 2009Review
- Regulators affecting the metastasis suppressor activity of Nm23-H1.Molecular and cellular biochemistry · 2009Review
- The NM23 family in development.Molecular and cellular biochemistry · 2009Review
- A differential proteomic approach reveals an evolutionary conserved regulation of Nme proteins by Fe65 in C. elegans and mouse.Neurochemical research · 2008Article
- Phosphorylation of nm23-H1 by CKI induces its complex formation with h-prune and promotes cell motility.Oncogene · 2008Article
- Understanding h-prune biology in the fight against cancer.Clinical & experimental metastasis · 2007Review
- PRUNE and NM23-M1 expression in embryonic and adult mouse brain.Journal of bioenergetics and biomembranes · 2006Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cancer is a multi-step process, one of the latest events correspond to metastasis formation and dissemination, to date the major cause of deaths. The h-prune-nm23-H1 protein complex and its activation of PDE-cAMP activity have been shown to correlate with breast cancer progression and metastasis formation. Here, we describe the protein complex formation and its involvement in cell migration. By gene expression studies and protein-protein pull-down analyses coupled to mass spectrometry we have identified new genes and pathways along which the h-prune-nm23-H1 complex exerts its function. We review here h-prune binding to the glycogen synthase kinase (GSK-3beta) and identify a new h-prune protein partner, Gelsolin, an ATP severing protein acting in focal adhesions, in a MDA-435 breast cancer cellular model. The results presented here underline the importance of this protein complex leading to new translational studies involved into the inhibition of cell migration, thus enhancing the potential of using this knowledge to direct inhibition of metastases formation in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.