ArticleMammalian genome : official journal of the International Mammalian Genome Society2006
Quantitative trait loci for individual adipose depot weights in C57BL/6ByJ x 129P3/J F2 mice.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 30 citations in OpenAlex.
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- Adipogenesis of ear mesenchymal stem cells (EMSCs): adipose biomarker-based assessment of genetic variation, adipocyte function, and brown/brite differentiation.Molecular and cellular biochemistry · 2022Article
- Heritability of fat distributions in male mice from the founder strains of the Diversity Outbred mouse population.G3 (Bethesda, Md.) · 2021Article
- Burly1 is a mouse QTL for lean body mass that maps to a 0.8-Mb region of chromosome 2.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Article
- C57BL/6J mice as a polygenic developmental model of diet-induced obesity.Physiological reports · 2017Article
- Adiposity QTL Adip20 decomposes into at least four loci when dissected using congenic strains.PloS one · 2017Article
- Body Composition QTLs Identified in Intercross Populations Are Reproducible in Consomic Mouse Strains.PloS one · 2015Article
- Linking cellular zinc status to body weight and fat mass: mapping quantitative trait loci in Znt7 knockout mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2014Article
- QTL analysis of dietary obesity in C57BL/6byj X 129P3/J F2 mice: diet- and sex-dependent effects.PloS one · 2013Article
- Body fat distribution and organ weights of 14 common strains and a 22-strain consomic panel of rats.Physiology & behavior · 2011Article
- Genetic analysis of abdominal fat distribution in SM/J and A/J mice.Journal of lipid research · 2010Article
- Differential effects of sucrose and fructose on dietary obesity in four mouse strains.Physiology & behavior · 2010Article
- Mouse hepatic lipase alleles with variable effects on lipoprotein composition and size.Journal of lipid research · 2010Article
- Gene discovery and the genetic basis of calcium consumption.Physiology & behavior · 2008Review
- Candidate genes for obesity revealed from a C57BL/6J x 129S1/SvImJ intercross.International journal of obesity (2005) · 2008Article
- Mechanisms of hepatic steatosis in mice fed a lipogenic methionine choline-deficient diet.Journal of lipid research · 2008Article
- QTL for body composition on chromosome 7 detected using a chromosome substitution mouse strain.Obesity (Silver Spring, Md.) · 2008Article
- Reduced body weight is a common effect of gene knockout in mice.BMC genetics · 2008Article
- Genetic loci affecting body weight and fatness in a C57BL/6J x PWK/PhJ mouse intercross.Mammalian genome : official journal of the International Mammalian Genome Society · 2007Article
- A locus on mouse Chromosome 9 (Adip5) affects the relative weight of the gonadal but not retroperitoneal adipose depot.Mammalian genome : official journal of the International Mammalian Genome Society · 2006Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
To understand how genotype influences fat patterning and obesity, we conducted an autosomal genome scan using male and female F(2) hybrids between the C57BL/6ByJ and 129P3/J parental mouse strains. Mice were studied in middle-adulthood and were fed a low-energy, low-fat diet during their lifetime. We measured the weight of the retroperitoneal adipose depot (near the kidney) and the gonadal adipose depot (near the epididymis in males and ovaries in females). An important feature of the analysis was the comparison of linkage results for absolute adipose depot weight and depot weight adjusted for body size, i.e., relative weight. We detected 67 suggestive linkages for six phenotypes, which fell into one of three categories: those specific to absolute but not relative depot weight (Chr 5, 11, and 14), those specific to relative but not absolute depot weight (Chr 9, 15, and 16), and those involving both (Chr 2 and 7). Some quantitative trait loci (QTLs) affected one adipose depot more than another: Retroperitoneal depot weight was linked to Chr 8, 11, 12, and 17, but the linkage effects for the gonadal depot were stronger for Chr 5, 7, and 9. Several linkages were specific to sex; for instance, the absolute weight of gonadal fat was linked to Chromosome 7 in male (LOD = 3.4) but not female mice (LOD = 0.2). Refining obesity as a phenotype may uncover clues about gene function that will assist in positional cloning efforts.
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