ArticleMammalian genome : official journal of the International Mammalian Genome Society2006
A locus on mouse Chromosome 9 (Adip5) affects the relative weight of the gonadal but not retroperitoneal adipose depot.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed.
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- Current status and progress of research on the ADP-dependent glucokinase gene.Frontiers in oncology · 2024Review
- Genetic identification of Ly75 as a novel quantitative trait gene for resistance to obesity in mice.Scientific reports · 2018Article
- Burly1 is a mouse QTL for lean body mass that maps to a 0.8-Mb region of chromosome 2.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Article
- Adiposity QTL Adip20 decomposes into at least four loci when dissected using congenic strains.PloS one · 2017Article
- Panx3 links body mass index and tumorigenesis in a genetically heterogeneous mouse model of carcinogen-induced cancer.Genome medicine · 2016Article
- Body Composition QTLs Identified in Intercross Populations Are Reproducible in Consomic Mouse Strains.PloS one · 2015Article
- Genome-wide association study for backfat thickness in Canchim beef cattle using Random Forest approach.BMC genetics · 2013Article
- QTL analysis of dietary obesity in C57BL/6byj X 129P3/J F2 mice: diet- and sex-dependent effects.PloS one · 2013Article
- Genetic analysis of abdominal fat distribution in SM/J and A/J mice.Journal of lipid research · 2010Article
- Differential effects of sucrose and fructose on dietary obesity in four mouse strains.Physiology & behavior · 2010Article
- Congenic and bioinformatics analyses resolved a major-effect Fob3b QTL on mouse Chr 15 into two closely linked loci.Mammalian genome : official journal of the International Mammalian Genome Society · 2010Article
- Genotype X diet interactions in mice predisposed to mammary cancer. I. Body weight and fat.Mammalian genome : official journal of the International Mammalian Genome Society · 2008Article
- Genetic loci affecting body weight and fatness in a C57BL/6J x PWK/PhJ mouse intercross.Mammalian genome : official journal of the International Mammalian Genome Society · 2007Article
- Quantitative trait loci for individual adipose depot weights in C57BL/6ByJ x 129P3/J F2 mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2006Article
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5 authors.
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Abstract
To identify the gene or genes on mouse Chromosome 9 that contribute to strain differences in fatness, we conducted an expanded mapping analysis to better define the region where suggestive linkage was found, using the F(2 )generation of an intercross between the C57BL/6ByJ and 129P3/J mouse strains. Six traits were studied: the summed weight of two adipose depots, the weight of each depot, analyzed individually (the gonadal and retroperitoneal depot), and the weight of each depot (summed and individual) relative to body size. We found significant linkage (LOD = 4.6) that accounted for the relative weight of the summed adipose depots, and another for the relative weight of the gonadal (LOD = 5.3) but not retroperitoneal (LOD = 0.9) adipose depot. This linkage is near marker rs30280752 (61.1 Mb, Build 34) and probably is equivalent to the quantitative trait locus (QTL) Adip5. Because the causal gene is unknown, we identified and evaluated several candidates within the confidence interval with functional significance to the body fatness phenotype (Il18, Acat1, Cyp19a1, Crabp1, Man2c1, Neil1, Mpi1, Csk, Lsm16, Adpgk, Bbs4, Hexa, Thsd4, Dpp8, Anxa2, and Lipc). We conclude that the Adip5 locus is specific to the gonadal adipose depot and that a gene or genes near the linkage peak may account for this QTL.
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