ReviewDigestive diseases and sciences2006
The complex functions of mast cells in chronic human liver diseases.
Review in Digestive diseases and sciences, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 44 citations in OpenAlex.
- Induction of tryptophan hydroxylase in the liver of s.c. tumor model of prostate cancer.Cancer science · 2020Article
- HLA-G Expressing Immune Cells in Immune Mediated Diseases.Frontiers in immunology · 2020Review
- Angiogenesis and Hepatic Fibrosis: Western and Chinese Medicine Therapies on the Road.Chinese journal of integrative medicine · 2018Review
- Role of Mast Cells in Regulation of T Cell Responses in Experimental and Clinical Settings.Clinical reviews in allergy & immunology · 2018Review
- The emerging role of mast cells in liver disease.American journal of physiology. Gastrointestinal and liver physiology · 2017Review
- Mechanisms of adaptation of the hepatic vasculature to the deteriorating conditions of blood circulation in liver cirrhosis.World journal of hepatology · 2016Review
- Are mast cells implicated in asphyxia?International journal of legal medicine · 2016Article
- Angiogenesis and liver fibrosis.World journal of hepatology · 2015Review
- Liver fibrosis and mechanisms of the protective action of medicinal plants targeting inflammation and the immune response.International journal of inflammation · 2015Review
- Mast cells and the liver aging process.Immunity & ageing : I & A · 2013Article
- Mast cells as a potential prognostic marker in prostate cancer.Disease markers · 2013Review
- Mast cell deficiency attenuates progression of atherosclerosis and hepatic steatosis in apolipoprotein E-null mice.American journal of physiology. Heart and circulatory physiology · 2012Article
- Secondary sclerosing cholangitis.Nature reviews. Gastroenterology & hepatology · 2009Review
- Experimental obstructive cholestasis: the wound-like inflammatory liver response.Fibrogenesis & tissue repair · 2008Article
- Vascular endothelial growth factor attenuates hepatic sinusoidal capillarization in thioacetamide-induced cirrhotic rats.World journal of gastroenterology · 2008Article
- Inflammation: a way to understanding the evolution of portal hypertension.Theoretical biology & medical modelling · 2007Review
- The mast cell integrates the splanchnic and systemic inflammatory response in portal hypertension.Journal of translational medicine · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mast cells (MCs) are multifunctional effector cells of the immune system. MCs were originally thought to be involved in IgE-associated immediate hypersensitivity and allergic disorders, but it is now known that they contain or elaborate an array of mediators with a multitude of effects on many other cells. A number of studies have found that MCs are involved in various liver diseases. Although still controversial, they seem to be involved in the liver's fibrotic response to chronic inflammation and parasitic infection. Hepatic fibrosis is the most frequent liver response to toxic, infectious, or metabolic agents. During the establishment of this pathological condition, there is an increase in the components of the basement membrane that leads to continuous basement membrane-like structures being raised within Disse's space and a decrease in the number of sinusoid endothelial fenestrae. This leads to a complex process called "sinusoidal capillarization." At the cellular level, liver fibrogenesis is initiated by hepatocyte necrosis, which induces the recruitment of a large number of inflammatory cells, including MCs, which can be considered the primary effectors of the process changing sinusoidal endothelial cells into capillary-type endothelial cells. We review the roles played by MCs in hepatic chronic diseases and describe a biopsy section of hepatic tissue taken from a patient with chronic C virus-related hepatitis showing diffuse sinusoidal capillarization and a high density of MCs. This observation has led us to hypothesize a relationship between these highly specialized cells and sinusoidal capillarization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.