ArticleDigestive diseases and sciences2006
Clostridium difficile-associated pouchitis.
Article in Digestive diseases and sciences, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00583076 (A Pilot Study of the Safety and Efficacy of AST-120 in the Treatment of Active Pouchitis), which is not on this map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Pilot Study of the Safety and Efficacy of AST-120 in the Treatment of Active Pouchitis
Who cites it
18 citing papers in PubMed, 80 citations in OpenAlex.
- Optimal Antibiotic Selection for the Treatment of Pouchitis After Ileal Pouch-Anal Anastomosis.Journal of inflammation research · 2026Review
- Diagnosis and Medical Treatment of Acute and Chronic Idiopathic Pouchitis in Inflammatory Bowel Disease.Medicina (Kaunas, Lithuania) · 2024Review
- Risk Factors Associated With Hospital Readmission and Costs for Pouchitis.Crohn's & colitis 360 · 2021Article
- Obesity Is Associated with Decreased Risk of Clostridium difficile Infection in Hospitalized Patients with Pouchitis.Digestive diseases and sciences · 2020Article
- Fecal microbiota transplantation forGastroenterology report · 2017Article
- Clostridium difficile infection: risk factors, diagnosis and management.Current treatment options in gastroenterology · 2015Article
- Two Patients with Fulminant Clostridium difficile Enteritis Who Had Not Undergone Total Colectomy: A Case Series and Review of the Literature.Case reports in surgery · 2015Article
- Impact of Clostridium difficile infection on inflammatory bowel disease outcome: a review.World journal of gastroenterology · 2014Review
- Innate immune environment in ileal pouch mucosa: α5 defensin up-regulation as predictor of chronic/relapsing pouchitis.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2012Article
- Clostridium difficile Infection and Inflammatory Bowel Disease: A Review.Gastroenterology research and practice · 2011Article
- Clostridium difficile infection and inflammatory bowel disease: understanding the evolving relationship.World journal of gastroenterology · 2010Article
- Fulminant Clostridium difficile-associated pouchitis with a fatal outcome.Nature reviews. Gastroenterology & hepatology · 2009Review
- Clostridium difficile and inflammatory bowel disease: implications for current clinical practice.F1000 medicine reports · 2009Article
- Recent developments on the role of Clostridium difficile in inflammatory bowel disease.World journal of gastroenterology · 2008Article
- Diagnosis and treatment of pouchitis.Gastroenterology & hepatology · 2008Article
- Catastrophic Clostridium difficile enteritis in a pelvic pouch patient: report of a case.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2008Article
- Microbial host interactions in IBD: implications for pathogenesis and therapy.Current gastroenterology reports · 2007Review
- Pouchitis.World journal of gastroenterology · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pouchitis is the most common long-term sequela of ileal pouch-anal anastomosis (IPAA) following total proctocolectomy. No single pathogen is identified as being solely responsible for the pathogenesis of the disease. Here we describe a case of Clostridium difficile-associated pouchitis that was successfully treated with ciprofloxacin and tinidazole. Diagnosis and management of a patient with medically refractory pouchitis associated with Clostridium difficile infection is described. A 63-year-old male with underlying ulcerative colitis and IPAA presented with increased stool frequency and seepage for 2 months, which partially responded to oral metronidazole. While on the antibiotic therapy, pouch endoscopy was performed and showed severe pouchitis. Assays for Clostridium difficile toxins in stool specimens were positive. He was treated with a 4-week course of ciprofloxacin 500 mg BID and tinidazole 500 mg TID. His symptoms resolved within several days from the initiation of therapy. A repeat pouch endoscopy at week 5 showed a complete resolution of mucosal inflammation of the pouch, while tests for Clostridium difficile toxins became negative. Clostridium difficile-associated pouchitis is rare. However, Clostridium difficile infection should be excluded in patients with chronic refractory pouchitis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.