ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2007
Midline "brain in brain": an unusual variant of holoprosencephaly with anterior prosomeric cortical dysplasia.
Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 7 citations in OpenAlex.
- Definitions and classification of malformations of cortical development: practical guidelines.Brain : a journal of neurology · 2020Review
- Subcortical heterotopic gray matter brain malformations: Classification study of 107 individuals.Neurology · 2019Article
- Subcortical heterotopia appearing as huge midline mass in the newborn brain.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2016Article
- Midline brain-in-brain malformation associated with bilateral perirolandic cortical abnormalities: an image review of this rare disorder.Pediatric radiology · 2012Review
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5 authors at 2 institutions in 2 countries.
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Abstract
introductionWe report three cases of brain malformation presenting with a midline mass of dysplastic cortex that we have termed "brain in brain" malformation.
resultsThe three cases have holoprosencephalic features, including bilateral hemispheric continuity across the midline, single ventricle, midline facial defect and missing olfactory bulbs. All three cases have a midline conglomerate mass of deeply infolded, cortex-lined fissures with major arterial branches, heterotopia and large amount of white matter. The dysplastic mass of cortex and white matter extended into the third ventricle. The cortex and white matter of the dysplastic lesion was continuous with the cortex and white matter, respectively, of the cerebral hemispheres.
conclusionThe midline "brain in brain" malformations have some similarities to subcortical heterotopia and extracerebral glioneuronal heterotopia. However, the continuity with the cerebral hemispheres and extension into the ventricle were not reported in subcortical or glioneuronal heterotopia. The common involvement of the midline cortex and extension into the third ventricle implied an anterior segmental prosencephalic abnormality (prosomeres 5/6). However, its pathogenesis remains to be explained.
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