ArticleProceedings of the National Academy of Sciences of the United States of America2006
Recurrent duplication-driven transposition of DNA during hominoid evolution.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed.
- Convergent evolution through independent rearrangements in the primate amylase locus.Cell reports · 2026Article
- Evolutionary instability drives structural diversity and disease susceptibility at the 16p12.2 locus.bioRxiv : the preprint server for biology · 2026Article
- Structural variation, selection, and diversification of the NPIP gene family from the human pangenome.Cell genomics · 2025Article
- Independent expansion, selection, and hypervariability of theGenome research · 2024Article
- Impact and characterization of serial structural variations across humans and great apes.Nature communications · 2024Article
- Independent expansion, selection and hypervariability of thebioRxiv : the preprint server for biology · 2024Article
- Genomic structural variation: A complex but important driver of human evolution.American journal of biological anthropology · 2023Review
- SVA Retrotransposons and a Low Copy Repeat in Humans and Great Apes: A Mobile Connection.Molecular biology and evolution · 2022Article
- Alpha Satellite Insertion Close to an Ancestral Centromeric Region.Molecular biology and evolution · 2021Article
- Association of structural variation with cardiometabolic traits in Finns.American journal of human genetics · 2021Article
- 22q11.2 Low Copy Repeats Expanded in the Human Lineage.Frontiers in genetics · 2021Article
- Genomic Chaos Begets Psychiatric Disorder.Complex psychiatry · 2020Review
- An evolutionary driver of interspersed segmental duplications in primates.Genome biology · 2020Article
- Refining the Phenotype of Recurrent Rearrangements of Chromosome 16.International journal of molecular sciences · 2019Article
- Continuous-Trait Probabilistic Model for Comparing Multi-species Functional Genomic Data.Cell systems · 2018Article
- Review
- Human adaptation and evolution by segmental duplication.Current opinion in genetics & development · 2016Review
- Interchromosomal core duplicons drive both evolutionary instability and disease susceptibility of the Chromosome 8p23.1 region.Genome research · 2016Article
- Male-specific region of the bovine Y chromosome is gene rich with a high transcriptomic activity in testis development.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Mechanisms for Structural Variation in the Human Genome.Current genetic medicine reports · 2013Article
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9 authors.
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Abstract
The underlying mechanism by which the interspersed pattern of human segmental duplications has evolved is unknown. Based on a comparative analysis of primate genomes, we show that a particular segmental duplication (LCR16a) has been the source locus for the formation of the majority of intrachromosomal duplications blocks on human chromosome 16. We provide evidence that this particular segment has been active independently in each great ape and human lineage at different points during evolution. Euchromatic sequence that flanks sites of LCR16a integration are frequently lineage-specific duplications. This process has mobilized duplication blocks (15-200 kb in size) to new genomic locations in each species. Breakpoint analysis of lineage-specific insertions suggests coordinated deletion of repeat-rich DNA at the target site, in some cases deleting genes in that species. Our data support a model of duplication where the probability that a segment of DNA becomes duplicated is determined by its proximity to core duplicons, such as LCR16a.
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