ArticleLearning & memory (Cold Spring Harbor, N.Y.)
Age-dependent glutamate induction of synaptic plasticity in cultured hippocampal neurons.
Article in Learning & memory (Cold Spring Harbor, N.Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Development and validation of a nomogram for prediction of survival in adolescent spinal cord injury patients.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Article
- Brain-Behavior Relationships: Neural Mechanisms of Impulsivity and Compulsivity in Neuropsychiatric Disorders.Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology · 2025Review
- The Biology and Pathobiology of Glutamatergic, Cholinergic, and Dopaminergic Signaling in the Aging Brain.Frontiers in aging neuroscience · 2021Review
- Overshooting Subcellular Redox-Responses in Rett-Mouse Hippocampus during Neurotransmitter Stimulation.Cells · 2020Article
- From 2D to 3D: novel nanostructured scaffolds to investigate signalling in reconstructed neuronal networks.Scientific reports · 2015Article
- Article
- Cationic amino acid based lipids as effective nonviral gene delivery vectors for primary cultured neurons.ACS chemical neuroscience · 2013Article
- Rapid and long-lasting increase in sites for synapse assembly during late-phase potentiation in rat hippocampal neurons.PloS one · 2009Article
- Impact of age on long-term recovery from traumatic brain injury.Archives of physical medicine and rehabilitation · 2008Article
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Authors and funding
3 authors.
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Abstract
A common denominator for the induction of morphological and functional plasticity in cultured hippocampal neurons involves the activation of excitatory synapses. We now demonstrate massive morphological plasticity in mature cultured hippocampal neurons caused by a brief exposure to glutamate. This plasticity involves a slow, 70%-80% increase in spine cross-section area associated with a significant reduction in the width of dendrites. These changes are age dependent and expressed only in cells >18 d in vitro (DIV). Activation of both NMDARs and AMPARs as well as a sustained rise of internal calcium levels are necessary for induction of this plasticity. On the other hand, blockade of network activity or mGluRs does not abolish the observed morphological plasticity. Electrophysiologically, a brief exposure to glutamate induces an increase in the magnitude of EPSCs evoked between pairs of neurons, as well as in mEPSC frequency and amplitude, in mature but not young cultures. These results demonstrate an age-dependent, rapid and robust morphological and functional change in cultured central neurons that may contribute to their ability to express long term synaptic plasticity.
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