ArticleMolecular and cellular biology2007
HP1 proteins are essential for a dynamic nuclear response that rescues the function of perturbed heterochromatin in primary human cells.
Article in Molecular and cellular biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
41 citing papers in PubMed, 62 citations in OpenAlex.
- Phase II trial of vorinostat in advanced melanoma.Investigational new drugs · 2014Trial
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- Epigenetic impairments in development of parthenogenetic preimplantation mouse embryos.The Journal of reproduction and development · 2019Article
- Promyelocytic leukemia (PML) nuclear bodies (NBs) induce latent/quiescent HSV-1 genomes chromatinization through a PML NB/Histone H3.3/H3.3 Chaperone Axis.PLoS pathogens · 2018Article
- Epigenetics in Turner syndrome.Clinical epigenetics · 2018Review
- A Molecular Prospective for HIRA Complex Assembly and H3.3-Specific Histone Chaperone Function.Journal of molecular biology · 2017Review
- Ubinuclein-1 confers histone H3.3-specific-binding by the HIRA histone chaperone complex.Nature communications · 2015Article
- MTA family of proteins in DNA damage response: mechanistic insights and potential applications.Cancer metastasis reviews · 2014Review
- Chromatin maintenance and dynamics in senescence: a spotlight on SAHF formation and the epigenome of senescent cells.Chromosoma · 2014Review
- Chromatin dynamics during DNA repair revealed by pair correlation analysis of molecular flow in the nucleus.Biophysical journal · 2014Article
- Histone variants: emerging players in cancer biology.Cellular and molecular life sciences : CMLS · 2014Review
- Identification of ribonucleotide reductase M2 as a potential target for pro-senescence therapy in epithelial ovarian cancer.Cell cycle (Georgetown, Tex.) · 2014Article
- Differential distribution of HP1 proteins after trichostatin a treatment influences chromosomal stability in HCT116 and WI-38 cells.Cell division · 2014Article
- Dynamics of histone H3.3 deposition in proliferating and senescent cells reveals a DAXX-dependent targeting to PML-NBs important for pericentromeric heterochromatin organization.Cell cycle (Georgetown, Tex.) · 2014Article
- BRG1 is required for formation of senescence-associated heterochromatin foci induced by oncogenic RAS or BRCA1 loss.Molecular and cellular biology · 2013Article
- Suppression of nucleotide metabolism underlies the establishment and maintenance of oncogene-induced senescence.Cell reports · 2013Article
- HP1γ expression is elevated in prostate cancer and is superior to Gleason score as a predictor of biochemical recurrence after radical prostatectomy.BMC cancer · 2013Article
- Detection of senescence-associated heterochromatin foci (SAHF).Methods in molecular biology (Clifton, N.J.) · 2013Article
- Oncogenic RAS regulates BRIP1 expression to induce dissociation of BRCA1 from chromatin, inhibit DNA repair, and promote senescence.Developmental cell · 2011Article
- Histone variant H3.3 stimulates HSP70 transcription through cooperation with HP1γ.Nucleic acids research · 2011Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Cellular information is encoded genetically in the DNA nucleotide sequence and epigenetically by the "histone code," DNA methylation, and higher-order packaging of DNA into chromatin. Cells possess intricate mechanisms to sense and repair damage to DNA and the genetic code. However, nothing is known of the mechanisms, if any, that repair and/or compensate for damage to epigenetically encoded information, predicted to result from perturbation of DNA and histone modifications or other changes in chromatin structure. Here we show that primary human cells respond to a variety of small molecules that perturb DNA and histone modifications by recruiting HP1 proteins to sites of altered pericentromeric heterochromatin. This response is essential to maintain the HP1-binding kinetochore protein hMis12 at kinetochores and to suppress catastrophic mitotic defects. Recruitment of HP1 proteins to pericentromeres depends on histone H3.3 variant deposition, mediated by the HIRA histone chaperone. These data indicate that defects in pericentromeric epigenetic heterochromatin modifications initiate a dynamic HP1-dependent response that rescues pericentromeric heterochromatin function and is essential for viable progression through mitosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.