ArticleInfection and immunity2007
Differential liver protein expression during schistosomiasis.
Article in Infection and immunity, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 57 citations in OpenAlex.
- Metabolomic analysis of the intrinsic resistance mechanisms of Microtus fortis against Schistosoma japonicum infection.Scientific reports · 2025Article
- Article
- In vitro evaluation of the effect of galectins on Schistosoma mansoni motility.BMC research notes · 2023Article
- Efficacy ofJournal of traditional and complementary medicine · 2019Article
- The influence of trematode parasite burden on gene expression in a mammalian host.BMC genomics · 2016Article
- Identification of Candidate Serum Biomarkers for Schistosoma mansoni Infected Mice Using Multiple Proteomic Platforms.PloS one · 2016Article
- Human plasma lipid modulation in schistosomiasis mansoni depends on apolipoprotein E polymorphism.PloS one · 2014Article
- Therapeutic effect of alpha lipoic acid combined with praziquantel on liver fibrosis induced by Schistosoma mansoni challenged mice.Parasitology research · 2012Article
- Proteomic changes at 8 weeks after infection are associated with chronic liver pathology in experimental schistosomiasis.Journal of proteomics · 2012Article
- Differential expression of chemokine and matrix re-modelling genes is associated with contrasting schistosome-induced hepatopathology in murine models.PLoS neglected tropical diseases · 2011Article
- IL-4/STAT6 immune axis regulates peripheral nutrient metabolism and insulin sensitivity.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Metabolic changes reveal the development of schistosomiasis in mice.PLoS neglected tropical diseases · 2010Article
- Modulation of the arginase pathway in the context of microbial pathogenesis: a metabolic enzyme moonlighting as an immune modulator.PLoS pathogens · 2010Review
- Co-ordinated gene expression in the liver and spleen during Schistosoma japonicum infection regulates cell migration.PLoS neglected tropical diseases · 2010Article
- Temporal expression of chemokines dictates the hepatic inflammatory infiltrate in a murine model of schistosomiasis.PLoS neglected tropical diseases · 2010Article
- Differential patterns of liver proteins in experimental murine hepatosplenic schistosomiasis.Infection and immunity · 2010Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The arrival of eggs in the liver during Schistosoma mansoni infection initiates a protective granulomatous response; however, as the infection progresses, this response results in chronic liver fibrosis. To better understand the impact of schistosomiasis on liver function, we used a proteomic approach to identify proteins whose expression was significantly altered in schistosome-infected mice 8 weeks postinfection. Identification of differentially expressed proteins by mass fingerprinting revealed that schistosome infection markedly reduced the abundance of proteins associated with several normal liver functions (i.e., citric acid cycle, fatty acid cycle, and urea cycle), while proteins associated with stress responses, acute phase reactants, and structural components were all significantly more abundant. The expression patterns of several immunity-related proteins (peroxiredoxin 1, arginase 1, and galectin 1) suggested that different protein forms are associated with schistosome infection. These findings indicate that acute schistosomiasis has a significant impact on specific liver functions and, moreover, that the alterations in specific protein isoforms and upregulation of unique proteins may be valuable as new markers of disease.
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