ArticleInfection and immunity2007
The Rab6 effector Bicaudal D1 associates with Chlamydia trachomatis inclusions in a biovar-specific manner.
Article in Infection and immunity, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 52 citations in OpenAlex.
- Movement of the endoplasmic reticulum is driven by multiple classes of vesicles marked by Rab-GTPases.Molecular biology of the cell · 2025Article
- Hijacking host cell vesicular transport: New insights into the nutrient acquisition mechanism ofVirulence · 2024Review
- ThemBio · 2023Article
- Rab6 regulates cell migration and invasion by recruiting Cdc42 and modulating its activity.Cellular and molecular life sciences : CMLS · 2019Article
- Purification and proteomics of pathogen-modified vacuoles and membranes.Frontiers in cellular and infection microbiology · 2015Review
- The eukaryotic signal sequence, YGRL, targets the chlamydial inclusion.Frontiers in cellular and infection microbiology · 2014Article
- Modulation of host signaling and cellular responses by Chlamydia.Cell communication and signaling : CCS · 2013Review
- Vesicle-associated membrane protein 4 and syntaxin 6 interactions at the chlamydial inclusion.Infection and immunity · 2013Article
- Bicaudal-D uses a parallel, homodimeric coiled coil with heterotypic registry to coordinate recruitment of cargos to dynein.Genes & development · 2013Article
- Chlamydial intracellular survival strategies.Cold Spring Harbor perspectives in medicine · 2013Review
- Bacterial pathogens commandeer Rab GTPases to establish intracellular niches.Traffic (Copenhagen, Denmark) · 2012Review
- Sphingolipid trafficking and purification in Chlamydia trachomatis-infected cells.Current protocols in microbiology · 2012Article
- Chlamydial infection induces host cytokinesis failure at abscission.Cellular microbiology · 2012Article
- Chlamydia trachomatis hijacks intra-Golgi COG complex-dependent vesicle trafficking pathway.Cellular microbiology · 2012Article
- Recent advances in Chlamydia subversion of host cytoskeletal and membrane trafficking pathways.Microbes and infection · 2011Review
- A role for the small GTPase Rab6 in assembly of human cytomegalovirus.Journal of virology · 2011Article
- Article
- Genetic predictors of medically refractory ulcerative colitis.Inflammatory bowel diseases · 2010Article
- The Anaplasma phagocytophilum-occupied vacuole selectively recruits Rab-GTPases that are predominantly associated with recycling endosomes.Cellular microbiology · 2010Article
- Multiple host proteins that function in phosphatidylinositol-4-phosphate metabolism are recruited to the chlamydial inclusion.Infection and immunity · 2010Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Chlamydia species are obligate intracellular bacteria that replicate within a membrane-bound vacuole, the inclusion, which is trafficked to the peri-Golgi region by processes that are dependent on early chlamydial gene expression. Although neither the host nor the chlamydial proteins that regulate the intracellular trafficking have been clearly defined, several enhanced green fluorescent protein (EGFP)-tagged Rab GTPases, including Rab6, are recruited to Chlamydia trachomatis inclusions. To further characterize the association of Rab6 with C. trachomatis inclusions, we examined the intracellular localization of guanine nucleotide-binding mutants of Rab6 and demonstrated that only active GTP-bound and not inactive GDP-bound EGFP-Rab6 mutants were recruited to the inclusion, suggesting that EGFP-Rab6 interacts with the inclusion via a host Rab6 effector or a chlamydial protein that mimics a Rab6 effector. Using EGFP-tagged fusion proteins, we also demonstrated that the Rab6 effector Bicaudal D1 (BICD1) localized to C. trachomatis inclusions in a biovar-specific manner. In addition, we demonstrated that EGFP-Rab6 and its effector EGFP-BICD1 are recruited to the inclusion in a microtubule- and Golgi apparatus-independent but chlamydial gene expression-dependent mechanism. Finally, in contrast to the Rab6-dependent Golgi apparatus localization of endogenous BICD1, EGFP-BICD1 was recruited to the inclusion by a Rab6-independent mechanism. Collectively, these data demonstrate that neither Rab6 nor BICD1 is trafficked to the inclusion via a Golgi apparatus-localized intermediate, suggesting that each protein is trafficked to the C. trachomatis serovar L2 inclusion by a unique, but as-yet-undefined, mechanism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.