ArticleJournal of the American Society for Mass Spectrometry2007
A pulsed triple ionization source for sequential ion/ion reactions in an electrodynamic ion trap.
Article in Journal of the American Society for Mass Spectrometry, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Ion-Ion Chemistry for the Analysis of Biomolecular Ions via Tandem Mass Spectrometry: A Tutorial Review.Annual review of analytical chemistry (Palo Alto, Calif.) · 2026Review
- Gas-Phase Covalent Bond Formation via Nucleophilic Substitution: A Dissociation Kinetics Study of Leaving Groups, Isomeric R Groups, and Nucleophilic Sites.Journal of the American Society for Mass Spectrometry · 2022Article
- Adaptation and Operation of a Quadrupole/Time-of-Flight Tandem Mass Spectrometer for High Mass Ion/Ion Reaction Studies.International journal of mass spectrometry · 2022Article
- Multiply Charged Cation Attachment to Facilitate Mass Measurement in Negative-Mode Native Mass Spectrometry.Analytical chemistry · 2022Article
- Manipulation of Ion Types via Gas-Phase Ion/Ion Chemistry for the Structural Characterization of the Glycan Moiety on Gangliosides.Analytical chemistry · 2021Article
- Triboelectric nanogenerators for sensitive nano-coulomb molecular mass spectrometry.Nature nanotechnology · 2017Article
- Strategies for the Gas Phase Modification of Cationized Arginine via Ion/ion Reactions.International journal of mass spectrometry · 2013Article
- Reagent cluster anions for multiple gas-phase covalent modifications of peptide and protein cations.Journal of the American Society for Mass Spectrometry · 2013Article
- Gas-phase transformation of phosphatidylcholine cations to structurally informative anions via ion/ion chemistry.Analytical chemistry · 2013Article
- Gas-phase reactivity of carboxylic acid functional groups with carbodiimides.Journal of the American Society for Mass Spectrometry · 2013Article
- Ion/ion reactions of MALDI-derived peptide ions: increased sequence coverage via covalent and electrostatic modification upon charge inversion.Analytical chemistry · 2012Article
- Covalent and non-covalent binding in the ion/ion charge inversion of peptide cations with benzene-disulfonic acid anions.Journal of mass spectrometry : JMS · 2012Article
- Dissociation Behavior of Tryptic and Intramolecular Disulfide-linked Peptide Ions Modified in the Gas Phase via Ion/Ion Reactions.International journal of mass spectrometry · 2012Article
- An ion trap-ion mobility-time of flight mass spectrometer with three ion sources for ion/ion reactions.Journal of the American Society for Mass Spectrometry · 2009Article
- Transmission mode ion/ion reactions in the radiofrequency-only ion guide of hybrid tandem mass spectrometers.Rapid communications in mass spectrometry : RCM · 2009Article
- The role of amino acid composition in the charge inversion of deprotonated peptides via gas-phase ion/ion reactions.Journal of the American Society for Mass Spectrometry · 2009Article
- Pulsed Nano-Electrospray Ionization: Characterization of Temporal Response and Implementation with a Flared Inlet Capillary.Instrumentation science & technology · 2009Article
- A linear ion trap mass spectrometer with versatile control and data acquisition for ion/ion reactions.Journal of the American Society for Mass Spectrometry · 2008Article
- Evolution of instrumentation for the study of gas-phase ion/ion chemistry via mass spectrometry.Journal of the American Society for Mass Spectrometry · 2008Review
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Authors and funding
4 authors.
Funding
Abstract
A pulsed triple ionization source, using a common atmosphere/vacuum interface and ion path, has been developed to generate different types of ions for sequential ion/ion reaction experiments in a linear ion trap-based tandem mass spectrometer. The triple ionization source typically consists of a nano-electrospray emitter for analyte formation and two other emitters, an electrospray emitter and an atmospheric pressure chemical ionization emitter or a second nano-electrospray emitter for formation of the two different reagent ions. The three emitters are positioned in a parallel fashion close to the sampling orifice of the tandem mass spectrometer. The potentials applied to each emitter are sequentially pulsed so that desired ions are generated separately in time and space. Sequential ion/ion reactions take place after analyte ions of interest and different set of reagent ions are sequentially injected into a linear ion trap, where axial trapping is effected by applying an auxiliary radio frequency voltage to the end lenses. The pulsed triple ionization source allows independent optimization of each emitter and can be readily coupled to any atmospheric pressure ionization interface with no need for instrument modifications, provided the potentials required to transmit the ion polarity of interest can be synchronized with the emitter potentials. Several sequential ion/ion reactions examples are demonstrated to illustrate the analytical usefulness of the triple ionization source in the study of gas-phase ion/ion chemistry.
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Registered trials
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