ReviewDevelopmental biology2006
High regulatory gene use in sea urchin embryogenesis: Implications for bilaterian development and evolution.
Review in Developmental biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed.
- Expression of Hox Genes in Early Development of Irregular Sea Urchin Scaphechinus mirabilis (Echinodermata, Echinoidea).Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections · 2025Article
- Combinatorial regulatory states define cell fate diversity during embryogenesis.Nature communications · 2024Article
- Article
- The temporal dynamics of the sea urchin regulome.Biology open · 2022Article
- A Survey on Tubulin and Arginine Methyltransferase Families Sheds Light onInternational journal of molecular sciences · 2019Article
- Neurogenesis in the sea urchin embryo is initiated uniquely in three domains.Development (Cambridge, England) · 2018Article
- Developmental transcriptomics of the brittle star Amphiura filiformis reveals gene regulatory network rewiring in echinoderm larval skeleton evolution.Genome biology · 2018Article
- Regulatory states in the developmental control of gene expression.Briefings in functional genomics · 2017Review
- Echinobase: an expanding resource for echinoderm genomic information.Database : the journal of biological databases and curation · 2017Article
- Article
- Quantitative developmental transcriptomes of the sea urchin Strongylocentrotus purpuratus.Developmental biology · 2014Article
- Phylogenomics of strongylocentrotid sea urchins.BMC evolutionary biology · 2013Article
- Gene structure in the sea urchin Strongylocentrotus purpuratus based on transcriptome analysis.Genome research · 2012Article
- The gene regulatory network basis of the "community effect," and analysis of a sea urchin embryo example.Developmental biology · 2010Review
- The endoderm gene regulatory network in sea urchin embryos up to mid-blastula stage.Developmental biology · 2010Article
- Functional cis-regulatory genomics for systems biology.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Echinoderms: potential model systems for studies on muscle regeneration.Current pharmaceutical design · 2010Review
- SpBase: the sea urchin genome database and web site.Nucleic acids research · 2009Article
- A new method, using cis-regulatory control, for blocking embryonic gene expression.Developmental biology · 2008Article
- The sea urchin genome as a window on function.The Biological bulletin · 2008Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
A global scan of transcription factor usage in the sea urchin embryo was carried out in the context of the Strongylocentrotus purpuratus genome sequencing project, and results from six individual studies are here considered. Transcript prevalence data were obtained for over 280 regulatory genes encoding sequence-specific transcription factors of every known family, but excluding genes encoding zinc finger proteins. This is a statistically inclusive proxy for the total "regulome" of the sea urchin genome. Close to 80% of the regulome is expressed at significant levels by the late gastrula stage. Most regulatory genes must be used repeatedly for different functions as development progresses. An evolutionary implication is that animal complexity at the stage when the regulome first evolved was far simpler than even the last common bilaterian ancestor, and is thus of deep antiquity.
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