ArticleClinical and experimental immunology2006
Interleukin 18 maintains a long-standing inflammation in coeliac disease patients.
Article in Clinical and experimental immunology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Diet and psoriasis, part II: celiac disease and role of a gluten-free diet.Journal of the American Academy of Dermatology · 2014Pooled it
- Transcriptomics and eQTLs reveal inflammatory heterogeneity in the duodenal lining in coeliac disease.Genes and immunity · 2025Article
- LINE-1 hypomethylation characterizes the inflammatory response in coeliac disease associated-intestinal mucosa and small bowel adenocarcinomas.The Journal of pathology · 2025Article
- Role of interleukin-18 in mediating the impacts of celiac disease on osteoporosis: a Mendelian randomization study.Frontiers in immunology · 2024Article
- Programmed Cell Death in the Small Intestine: Implications for the Pathogenesis of Celiac Disease.International journal of molecular sciences · 2021Review
- Signals from the various immune cells in promoting food allergy-induced eosinophilic esophagitis like disease.Asia Pacific allergy · 2019Review
- Epithelial MHC Class II Expression and Its Role in Antigen Presentation in the Gastrointestinal and Respiratory Tracts.Frontiers in immunology · 2018Review
- Digestive system in psoriasis: an update.Archives of dermatological research · 2017Review
- Article
- Allergen-induced interleukin-18 promotes experimental eosinophilic oesophagitis in mice.Immunology and cell biology · 2015Article
- Involvement of interleukin-18 in the pathogenesis of human eosinophilic esophagitis.Clinical immunology (Orlando, Fla.) · 2015Article
- Interleukin-18 gene promoter polymorphisms and celiac disease in Italian patients.Molecular biology reports · 2015Article
- Cutting-edge issues in celiac disease and in gluten intolerance.Clinical reviews in allergy & immunology · 2012Review
- Evaluation of 6 candidate genes on chromosome 11q23 for coeliac disease susceptibility: a case control study.BMC medical genetics · 2010Article
- High levels of proinflammatory cytokines, but not markers of tissue injury, in unaffected intestinal areas from patients with IBD.Mediators of inflammation · 2009Article
- Higher constitutive IL15R alpha expression and lower IL-15 response threshold in coeliac disease patients.Clinical and experimental immunology · 2008Article
- Translational mini-review series on the immunogenetics of gut disease: immunogenetics of coeliac disease.Clinical and experimental immunology · 2008Review
- Infiltration of forkhead box P3-expressing cells in small intestinal mucosa in coeliac disease but not in type 1 diabetes.Clinical and experimental immunology · 2008Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dietary gluten induces an early response in the intestine of coeliac disease patients (CD), within a few hours, and this is driven by high levels of proinflammatory cytokines, including IFNgamma and IL-15, as has been thoroughly shown by gluten stimulation of biopsy explants. Our aim was to identify the immune mediators involved in the long-standing inflammation in untreated CD patients at diagnosis. mRNA and protein levels of TNFalpha, IL-12(p35), IL-12(p40), IL-15, IL-18 and IL-23(p19) were quantified in biopsies from active CD patients, CD patients on a gluten-free diet (GFD), healthy controls, and patients with non-CD inflammation and mild histological changes in the intestine. Biopsies from CD patients on a GFD were also stimulated in vitro with gliadin, and protein expression of IL-15 and IL-18 was analysed. Levels of IL-12 and IL-23 mRNA are nearly absent, and TNFalpha levels remain unchanged among different groups. Both the active and inactive forms of IL-18 protein have been found in all samples from active CD, and protein expression was only localized within the crypts. Levels of IL-15 mRNA remain unchanged, and protein expression, localized within the lamina propria, is found in a small number of samples. In vitro stimulation with gluten induces the expression of IL-15 and IL-18. In active CD, the early response following gluten intake characterized by high IFNgamma levels is driven by IL-18, and probably IL-15, and this alternates with periods of long-standing inflammation with moderate IFNgamma levels, maintained by IL-18 alone.
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