Evidence map›Paper›PMID 17099715›Full record

ArticleBone marrow transplantation2007

Central nervous system graft-versus-host disease: report of two cases and literature review.

R T Kamble, C-C Chang, S Sanchez, G Carrum

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in Bone marrow transplantation, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Central nervous system graft-versus-host disease in a 68-year-old man presenting with myoclonus.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2019
    Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Graft versus self (GvS) against T-cell autoantigens is a mechanism of graft-host interaction.Proceedings of the National Academy of Sciences of the United States of America · 2016
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

R T KambleCenter for Cell and Gene Therapy, Baylor College of Medicine and Methodist Hospital, Houston, TX 77030, USA. kamble@sbcglobal.net
C-C Chang
S Sanchez
G Carrum

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Two patients with a plausible diagnosis of central nervous system graft-versus-host disease (CNS-GVHD) are described. Both presented with neurological manifestations 6 and 18 months following allogeneic transplant with hemiparesis, seizure, encephalopathy and magnetic resonance findings of hyperintense white matter lesions on T-2 weighed images. Brain biopsy in one and autopsy in the other revealed profound perivascular lymphocytic infiltrates composed predominantly of T-lymphocytes that were of donor origin. Although an unequivocal diagnosis of CNS-GVHD is difficult to establish, the transplantation community should be aware of this controversial entity.

Indexed as

AdultBurkitt LymphomaFemaleGraft vs Host DiseaseHumansLymphoma, T-CellMiddle AgedParesisPrecursor Cell Lymphoblastic Leukemia-LymphomaSeizuresT-Lymphocytes

Identifiers

PMID17099715

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.