ArticleThorax2007
Genome-wide linkage analysis of pulmonary function in families of children with asthma in Costa Rica.
Article in Thorax, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00021840 (Genetic Epidemiology of Asthma in Costa Rica), which is not on this map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Genetic Epidemiology of Asthma in Costa Rica
Who cites it
9 citing papers in PubMed, 18 citations in OpenAlex.
- Association of VEGF polymorphisms with childhood asthma, lung function and airway responsiveness.The European respiratory journal · 2009Trial
- Polygenic heritability estimates in pharmacogenetics: focus on asthma and related phenotypes.Pharmacogenetics and genomics · 2013Article
- Association of SERPINE2 with asthma.Chest · 2011Article
- c-Kit is essential for alveolar maintenance and protection from emphysema-like disease in mice.American journal of respiratory and critical care medicine · 2011Article
- Significant evidence for linkage to chromosome 5q13 in a genome-wide scan for asthma in an extended pedigree resource.European journal of human genetics : EJHG · 2009Article
- Sex-stratified linkage analysis identifies a female-specific locus for IgE to cockroach in Costa Ricans.American journal of respiratory and critical care medicine · 2008Article
- Race, ethnicity and social class and the complex etiologies of asthma.Pharmacogenomics · 2008Review
- Asthma from a pharmacogenomic point of view.British journal of pharmacology · 2008Review
- Chronic obstructive pulmonary disease in Hispanics.American journal of respiratory and critical care medicine · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundAlthough asthma is highly prevalent among certain Hispanic subgroups, genetic determinants of asthma and asthma-related traits have not been conclusively identified in Hispanic populations. A study was undertaken to identify genomic regions containing susceptibility loci for pulmonary function and bronchodilator responsiveness (BDR) in Costa Ricans.
methodsEight extended pedigrees were ascertained through schoolchildren with asthma in the Central Valley of Costa Rica. Short tandem repeat (STR) markers were genotyped throughout the genome at an average spacing of 8.2 cM. Multipoint variance component linkage analyses of forced expiratory volume in 1 second (FEV(1)) and FEV(1)/ forced vital capacity (FVC; both pre-bronchodilator and post-bronchodilator) and BDR were performed in these eight families (pre-bronchodilator spirometry, n = 640; post-bronchodilator spirometry and BDR, n = 624). Nine additional STR markers were genotyped on chromosome 7. Secondary analyses were repeated after stratification by cigarette smoking.
resultsAmong all subjects, the highest logarithm of the odds of linkage (LOD) score for FEV(1) (post-bronchodilator) was found on chromosome 7q34-35 (LOD = 2.45, including the additional markers). The highest LOD scores for FEV(1)/FVC (pre-bronchodilator) and BDR were found on chromosomes 2q (LOD = 1.53) and 9p (LOD = 1.53), respectively. Among former and current smokers there was near-significant evidence of linkage to FEV(1)/FVC (post-bronchodilator) on chromosome 5p (LOD = 3.27) and suggestive evidence of linkage to FEV(1) on chromosomes 3q (pre-bronchodilator, LOD = 2.74) and 4q (post-bronchodilator, LOD = 2.66).
conclusionsIn eight families of children with asthma in Costa Rica, there is suggestive evidence of linkage to FEV(1) on chromosome 7q34-35. In these families, FEV(1)/FVC may be influenced by an interaction between cigarette smoking and a locus (loci) on chromosome 5p.
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