ArticleMolecular biology and evolution2007
The conversion of 3' UTRs into coding regions.
Article in Molecular biology and evolution, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
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- Emergence and Tandem Repeat-Mediated Elongation of a Translated De Novo Open Reading Frame in Human Oncogenic RNA Gene VPS9D1-AS1 (MYU).Genome biology and evolution · 2026Article
- Evolutionary Insights into the Length Variation of DNA Damage Response Proteins Across Eukaryotes.Genome biology and evolution · 2025Article
- Not Quite Lost in Translation: Mistranslation Alters Adaptive Landscape Topography and the Dynamics of Evolution.Molecular biology and evolution · 2023Article
- Foster thy young: enhanced prediction of orphan genes in assembled genomes.Nucleic acids research · 2022Article
- Mistranslation Reduces Mutation Load in Evolving Proteins through Negative Epistasis with DNA Mutations.Molecular biology and evolution · 2021Article
- Effective Population Size Predicts Local Rates but Not Local Mitigation of Read-through Errors.Molecular biology and evolution · 2021Article
- Readthrough Errors Purge Deleterious Cryptic Sequences, Facilitating the Birth of Coding Sequences.Molecular biology and evolution · 2020Article
- TA, GT and AC are significantly under-represented in open reading frames of prokaryotic and eukaryotic protein-coding genes.Molecular genetics and genomics : MGG · 2019Article
- The carboxy-terminus, a key regulator of protein function.Critical reviews in biochemistry and molecular biology · 2019Review
- Mistranslation can enhance fitness through purging of deleterious mutations.Nature communications · 2017Article
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- Inferring Orthologs: Open Questions and Perspectives.Genomics insights · 2016Review
- AnABlast: a new in silico strategy for the genome-wide search of novel genes and fossil regions.DNA research : an international journal for rapid publication of reports on genes and genomes · 2015Article
- The Recent De Novo Origin of Protein C-Termini.Genome biology and evolution · 2015Article
- On the Nature and Evolutionary Impact of Phenotypic Robustness Mechanisms.Annual review of ecology, evolution, and systematics · 2014Article
- Q&A: Evolutionary capacitance.BMC biology · 2013Article
- Compensatory evolution and the origins of innovations.Genetics · 2013Article
- Proto-genes and de novo gene birth.Nature · 2012Article
- Evolution of prokaryotic genes by shift of stop codons.Journal of molecular evolution · 2011Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
A possible origin of novel coding sequences is the removal of stop codons, leading to the inclusion of 3' untranslated regions (3' UTRs) within genes. We classified changes in the position of stop codons in closely related Saccharomyces species and in a mouse/rat comparison as either additions to or subtractions from coding regions. In both cases, the position of stop codons is highly labile, with more subtractions than additions found. The subtraction bias may be balanced by the input of new coding regions through gene duplication. Saccharomyces shows less stop codon lability than rodents, probably due to greater selective constraint. A higher proportion of 3' UTR incorporation events preserve frame in Saccharomyces. This higher proportion is consistent with the action of the [PSI(+)] prion as an evolutionary capacitor to facilitate 3' UTR incorporation in yeast.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.