ArticleNucleic acids research2006
Concentration dependent selection of targets by an SR splicing regulator results in tissue-specific RNA processing.
Article in Nucleic acids research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- Dissecting the enhancer gene regulatory network in early Drosophila spermatogenesis.Nature communications · 2025Article
- Concentration and Localization of Coexpressed ELAV/Hu Proteins Control Specificity of mRNA Processing.Molecular and cellular biology · 2015Article
- Ets1 and heat shock factor 1 regulate transcription of the Transformer 2β gene in human colon cancer cells.Journal of gastroenterology · 2013Article
- Half pint/Puf68 is required for negative regulation of splicing by the SR splicing factor Transformer2.RNA biology · 2013Article
- Activation and repression functions of an SR splicing regulator depend on exonic versus intronic-binding position.Nucleic acids research · 2012Article
- Molecular design of a splicing switch responsive to the RNA binding protein Tra2β.Nucleic acids research · 2011Article
- The gene transformer-2 of Sciara (Diptera, Nematocera) and its effect on Drosophila sexual development.BMC developmental biology · 2011Article
- The gene transformer-2 of Anastrepha fruit flies (Diptera, Tephritidae) and its evolution in insects.BMC evolutionary biology · 2010Article
- Control of alternative splicing by signal-dependent degradation of splicing-regulatory proteins.The Journal of biological chemistry · 2009Article
- A computational approach for genome-wide mapping of splicing factor binding sites.Genome biology · 2009Article
- The Fox-1 family and SUP-12 coordinately regulate tissue-specific alternative splicing in vivo.Molecular and cellular biology · 2007Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The splicing factor Transformer-2 (Tra2) is expressed almost ubiquitously in Drosophila adults, but participates in the tissue-specific regulation of splicing in several RNAs. In somatic tissues Tra2 participates in the activation of sex-specific splice sites in doublesex and fruitless pre-mRNAs. In the male germline it affects splicing of other transcripts and represses removal of the M1 intron from its own pre-mRNA. Here we test the hypothesis that the germline specificity of M1 repression is determined by tissue-specific differences in Tra2 concentration. We find that Tra2 is expressed at higher levels in primary spermatocytes of males than in other cell types. Increased Tra2 expression in other tissues reduces viability in a manner consistent with known dose-dependent effects of excessive Tra2 expression in the male germline. Somatic cells were found to be competent to repress M1 splicing if the level of Tra2 transcription was raised above endogenous concentrations. This suggests not only that M1 repression is restricted to the germline by a difference in Tra2 transcription levels but also that the protein's threshold concentration for M1 regulation differs from that of doublesex and fruitless RNAs. We propose that quantitative differences in regulator expression can give rise to cell-type-specific restrictions in splicing.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.