Evidence map›Paper›PMID 17098902›Full record

ArticleJournal of bacteriology2007

Contribution of invariant residues to the function of Rgg family transcription regulators.

Jennifer A Loughman, Michael G Caparon

Abstract read
In one paragraph

Article in Journal of bacteriology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Proteomic Characterization of Antibiotic Resistance inInternational journal of molecular sciences · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jennifer A LoughmanDepartment of Molecular Microbiology, Washington University School of Medicine, Saint Louis, MO 63110-1093, USA.
Michael G Caparon

Funding

PROTEASE AND ROP GENES IN S. PYOGENES VIRULENCER01AI046433 · NIAID · WASHINGTON UNIVERSITY · PI CAPARON, MICHAEL G. · 2000 to 2014
$4.7M
NIAID NIH HHS AI4643303
6 · The paper itself

Abstract

The Rgg family of transcription regulators is widely distributed among gram-positive bacteria, yet how these proteins control transcription is poorly understood. Using Streptococcus pyogenes RopB as a model, we demonstrated that residues invariant among Rgg-like regulators are critical for function and obtained evidence for a mechanism involving protein complex formation.

Indexed as

Transcription, GeneticAmino Acid MotifsBacterial ProteinsBlotting, WesternDNA-Binding ProteinsGene Expression Regulation, BacterialMutationStreptococcus pyogenesTrans-ActivatorsTryptophanBacterial ProteinsDNA-Binding Proteinsrgg protein, StreptococcusRopB protein, Rhizobium leguminosarumTrans-ActivatorsTryptophan

Identifiers

PMID17098902
PMCPMC1797381

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.