ArticleBiophysical journal2007
The mechanism of extracellular stimulation of nerve cells on an electrolyte-oxide-semiconductor capacitor.
Article in Biophysical journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 108 citations in OpenAlex.
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- A silicon diode-based optoelectronic interface for bidirectional neural modulation.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Unravelling the operation of organic artificial neurons for neuromorphic bioelectronics.Nature communications · 2024Article
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- A Retina-Inspired Optoelectronic Synapse Using Quantum Dots for Neuromorphic Photostimulation of Neurons.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- A Retina-Inspired Optoelectronic Synapse Using Quantum Dots for Neuromorphic Photostimulation of Neurons.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Assessment of chemotherapeutic effects on cancer cells using adhesion noise spectroscopy.Frontiers in bioengineering and biotechnology · 2024Article
- Wireless deep-brain neuromodulation using photovoltaics in the second near-infrared spectrum.Device · 2023Article
- MnOAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Bioresorbable thin-film silicon diodes for the optoelectronic excitation and inhibition of neural activities.Nature biomedical engineering · 2023Article
- A 3D biomimetic optoelectronic scaffold repairs cranial defects.Science advances · 2023Article
- Electrostatic polarization fields trigger glioblastoma stem cell differentiation.Nanoscale horizons · 2022Article
- Light Stimulation of Neurons on Organic Photocapacitors Induces Action Potentials with Millisecond Precision.Advanced materials technologies · 2022Article
- Nanoengineering InP Quantum Dot-Based Photoactive Biointerfaces for Optical Control of Neurons.Frontiers in neuroscience · 2021Article
- Bidirectional optical neuromodulation using capacitive charge-transfer.Biomedical optics express · 2020Article
- Organic Photovoltaic Pseudocapacitors for Neurostimulation.ACS applied materials & interfaces · 2020Article
- Efficient photocapacitors via ternary hybrid photovoltaic optimization for photostimulation of neurons.Biomedical optics express · 2020Article
- Low-Temperature Atomic Layer Deposited Oxide on Titanium Nitride Electrodes Enables Culture and Physiological Recording of Electrogenic Cells.Frontiers in neuroscience · 2020Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Extracellular excitation of neurons is applied in studies of cultured networks and brain tissue, as well as in neuroprosthetics. We elucidate its mechanism in an electrophysiological approach by comparing voltage-clamp and current-clamp recordings of individual neurons on an insulated planar electrode. Noninvasive stimulation of neurons from pedal ganglia of Lymnaea stagnalis is achieved by defined voltage ramps applied to an electrolyte/HfO2/silicon capacitor. Effects on the smaller attached cell membrane and the larger free membrane are distinguished in a two-domain-stimulation model. Under current-clamp, we study the polarization that is induced for closed ion channels. Under voltage-clamp, we determine the capacitive gating of ion channels in the attached membrane by falling voltage ramps and for comparison also the gating of all channels by conventional variation of the intracellular voltage. Neuronal excitation is elicited under current-clamp by two mechanisms: Rising voltage ramps depolarize the free membrane such that an action potential is triggered. Falling voltage ramps depolarize the attached membrane such that local ion currents are activated that depolarize the free membrane and trigger an action potential. The electrophysiological analysis of extracellular stimulation in the simple model system is a basis for its systematic optimization in neuronal networks and brain tissue.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.