ArticleBiophysical journal2007
Compartment-specific feedback loop and regulated trafficking can result in sustained activation of Ras at the Golgi.
Article in Biophysical journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Mesoscale simulations of membrane-tethered reactions to parameterize cell-scale models of signaling.Biophysical journal · 2026Article
- Live-cell quantitative monitoring reveals distinct, high-affinity Gβγ regulations of GIRK2 and GIRK1/2 channels.bioRxiv : the preprint server for biology · 2025Article
- Basal State Calibration of a Chemical Reaction Network Model for Autophagy.International journal of molecular sciences · 2024Article
- Modelling compartmentalization towards elucidation and engineering of spatial organization in biochemical pathways.Scientific reports · 2017Article
- Systems biology of cellular membranes: a convergence with biophysics.Wiley interdisciplinary reviews. Systems biology and medicine · 2017Review
- PLCε signaling in cancer.Journal of cancer research and clinical oncology · 2016Review
- Ras, an actor on many stages: posttranslational modifications, localization, and site-specified events.Genes & cancer · 2011Article
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- DHHC20: a human palmitoyl acyltransferase that causes cellular transformation.Molecular membrane biology · 2010Article
- Integration of a phosphatase cascade with the mitogen-activated protein kinase pathway provides for a novel signal processing function.The Journal of biological chemistry · 2010Article
- Use of virtual cell in studies of cellular dynamics.International review of cell and molecular biology · 2010Review
- Topology-based abstraction of complex biological systems: application to the Golgi apparatus.Theory in biosciences = Theorie in den Biowissenschaften · 2008Review
- Modelling cellular signalling systems.Essays in biochemistry · 2008Review
- Cellular palmitoylation and trafficking of lipidated peptides.Journal of lipid research · 2007Article
- Modeling of spatially-restricted intracellular signaling.Wiley interdisciplinary reviews. Systems biology and medicineReview
- Models at the single cell level.Wiley interdisciplinary reviews. Systems biology and medicineReview
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Imaging experiments have shown that cell signaling components such as Ras can be activated by growth factors at distinct subcellular locations. Trafficking between these subcellular locations is a regulated dynamic process. The effects of trafficking and the molecular mechanisms underlying compartment-specific Ras activation were studied using numerical simulations of an ordinary differential equation-based multi-compartment model. The simulations show that interplay between two distinct mechanisms, a palmitoylation cycle that controls Ras trafficking and a phospholipase C-epsilon (PLC-epsilon) driven feedback loop, can convert a transient calcium signal into prolonged Ras activation at the Golgi. Detailed analysis of the network identified PLC-epsilon as a key determinant of "compartment switching". Modulation of PLC-epsilon activity switches the location of activated Ras between the plasma membrane and Golgi through a new mechanism termed "kinetic scaffolding". These simulations indicate that multiple biochemical mechanisms, when appropriately coupled, can give rise to an intracellular compartment-specific sustained Ras activation in response to stimulation of growth factor receptors at the plasma membrane.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.