Trial reportJournal of vascular surgery2006
Prospective multicenter study of quality of life before and after lower extremity vein bypass in 1404 patients with critical limb ischemia.
Trial report in Journal of vascular surgery, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04730310 (Association of Anesthesia Technique With Graft Patency Rates After Open Lower Limb Revascularization), which is not on this map. Cited by 30 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Association of Anesthesia Technique With Graft Patency Rates After Open Lower Limb Revascularization: a Retrospective Population Cohort Study
Who cites it
30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 126 citations in OpenAlex.
- A systematic review of patient-reported outcome measures patients with chronic limb-threatening ischemia.Journal of vascular surgery · 2022Pooled it
- Global vascular guidelines on the management of chronic limb-threatening ischemia.Journal of vascular surgery · 2019Guideline
- Surgical complications and their impact on patients' psychosocial well-being: a systematic review and meta-analysis.BMJ open · 2016Pooled it
- Quality of Life in Patients With Chronic Limb-Threatening Ischemia Treated With Revascularization.Circulation · 2024Trial
- Disparity in outcomes of surgical revascularization for limb salvage: race and gender are synergistic determinants of vein graft failure and limb loss.Circulation · 2009Trial
- Risk stratification in critical limb ischemia: derivation and validation of a model to predict amputation-free survival using multicenter surgical outcomes data.Journal of vascular surgery · 2008Trial
- Revascularization in Nonagenarians with Chronic Limb-Threatening Ischemia Can Be Effective.Cardiovascular and interventional radiology · 2025Article
- Palliative surgery: state of the science and future directions.The British journal of surgery · 2024Article
- Six-year outcomes of a phase II study of human-tissue engineered blood vessels for peripheral arterial bypass.JVS-vascular science · 2023Article
- Article
- Impact of Longer Hemodialysis Vintage with Higher Serum Phosphorus Level on Clinical Outcomes in Patients with Chronic Limb-Threatening Ischemia Presenting Tissue Loss after Endovascular Therapy.Journal of atherosclerosis and thrombosis · 2022Article
- Impact of Bypass Flow Assessment on Long-Term Outcomes in Patients with Chronic Limb-Threatening Ischemia.World journal of surgery · 2021Article
- Effect of Target Lesion Revascularization on Restenosis Lesions of the Superficial Femoral Artery without Recurred Symptoms after Endovascular Therapy.Journal of atherosclerosis and thrombosis · 2021Article
- Two-year Outcome of Quality of Life and Health Status for the Elderly with Chronic Limb-threatening Ischemia.Clinical interventions in aging · 2020Observational
- Global Vascular Guidelines on the Management of Chronic Limb-Threatening Ischemia.European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery · 2019Article
- Quality of life after peripheral bypass surgery: a 1 year follow-up.Wiener klinische Wochenschrift · 2015Article
- Domains that Determine Quality of Life in Vascular Amputees.Annals of vascular surgery · 2015Article
- Gender differences in health status and adverse outcomes among patients with peripheral arterial disease.Journal of the American Heart Association · 2014Article
- Contemporary treatment for critical ischemia: the evidence for interventional radiology or surgery.Seminars in interventional radiology · 2014Review
- Hind limb ischemia-reperfusion injury in diet-induced obese mice.The Journal of surgical research · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundPatients with critical limb ischemia (CLI) have multiple comorbidities and limited life spans. The ability of infrainguinal vein bypass to improve quality of life (QoL) in patients with CLI has therefore been questioned. Prospective preoperative and postoperative QoL data for patients undergoing lower extremity vein bypass for CLI are presented.
methodsA validated, disease-specific QoL questionnaire (VascuQoL) with activity, symptom, pain, emotional, and social domains and responses scored 1 (lowest QoL) to 7 (best QoL) was administered before surgery and at 3 and 12 months after lower extremity vein bypass for CLI. Changes in QoL at 3 and 12 months after lower extremity vein bypass and multiple predetermined variables potentially influencing QoL after lower extremity vein bypass were analyzed to determine the effect of lower extremity vein bypass on QoL in CLI patients.
resultsA total of 1404 patients had lower extremity vein bypass for CLI at 83 centers in the United States and Canada as part of the PREVENT III clinical trial. Surveys were completed in 1296 patients at baseline, 862 patients at 3 months, and 732 patients at 12 months. The global QoL score (mean +/- SD) was 2.8 +/- 1.1 at baseline and was 4.7 +/- 1.4 and 5.1 +/- 1.4 at 3 and 12 months, respectively. Mean changes from baseline at 3 and 12 months were statistically significant (P < .0001). Improved QoL scores extended across all domains. Diabetes and the development of graft-related events were associated with decreased improvement in QoL scores, though the mean relative change from baseline remained positive.
conclusionsPatients with CLI have a low QoL at baseline that is improved at 3 and 12 months after lower extremity vein bypass. QoL improvements are lower in diabetic patients and those who develop graft-related events. Successful revascularization can be expected to improve QoL in patients with CLI, with benefits that are sustained to at least 1 year.
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Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.