ArticleInsect biochemistry and molecular biology2006
Molecular characterization of iron binding proteins from Glossina morsitans morsitans (Diptera: Glossinidae).
Article in Insect biochemistry and molecular biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- Lipid metabolism dysfunction following symbiont elimination is linked to altered Kennedy pathway homeostasis.iScience · 2023Article
- Insect-Symbiont Gene Expression in the Midgut Bacteriocytes of a Blood-Sucking Parasite.Genome biology and evolution · 2020Article
- Transcriptome Profiling of the WhiteflyFrontiers in physiology · 2019Article
- Gene expression in reproductive organs of tsetse females - initial data in an approach to reduce fecundity.BMC microbiology · 2018Article
- Rapid autophagic regression of the milk gland during involution is critical for maximizing tsetse viviparous reproductive output.PLoS neglected tropical diseases · 2018Article
- Molecular Characterization and Functional Analysis of a Ferritin Heavy Chain Subunit from the Eri-Silkworm, Samia cynthia ricini.International journal of molecular sciences · 2017Article
- Comparative genomics identifies male accessory gland proteins in fiveWellcome open research · 2017Article
- Hydrogen sulphide improves adaptation of Zea mays seedlings to iron deficiency.Journal of experimental botany · 2015Article
- Adenotrophic viviparity in tsetse flies: potential for population control and as an insect model for lactation.Annual review of entomology · 2015Review
- Prolonged pre-incubation increases the susceptibility of Galleria mellonella larvae to bacterial and fungal infection.Virulence · 2015Article
- Key enzymes and proteins of crop insects as candidate for RNAi based gene silencing.Frontiers in physiology · 2015Review
- A novel highly divergent protein family identified from a viviparous insect by RNA-seq analysis: a potential target for tsetse fly-specific abortifacients.PLoS genetics · 2014Article
- Amelioration of reproduction-associated oxidative stress in a viviparous insect is critical to prevent reproductive senescence.PloS one · 2014Article
- Lifestyle and host defense mechanisms of the dung beetle, Euoniticellus intermedius: the toll signaling pathway.Journal of insect science (Online) · 2013Article
- Insect ferritins: Typical or atypical?Biochimica et biophysica acta · 2010Review
- Wolbachia interferes with ferritin expression and iron metabolism in insects.PLoS pathogens · 2009Article
- Iron loaded ferritin secretion and inhibition by CI-976 in Aedes aegypti larval cells.Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology · 2009Article
- Identity and transfer of male reproductive gland proteins of the dengue vector mosquito, Aedes aegypti: potential tools for control of female feeding and reproduction.Insect biochemistry and molecular biology · 2008Article
- Molecular aspects of transferrin expression in the tsetse fly (Glossina morsitans morsitans).Journal of insect physiology · 2007Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The regulation of iron is critical for maintaining homeostasis in the tsetse fly (Diptera: Glossinidae), in which both adult sexes are strict blood feeders. We have characterized the cDNAs for two putative iron-binding proteins (IBPs) involved in transport and storage; transferrin (GmmTsf1) and ferritin from Glossina morsitans morsitans. GmmTsf1 transcripts are detected in the female fat body and in adult reproductive tissues, and only in the adult developmental stage in a bloodmeal independent manner. In contrast, the ferritin heavy chain (GmmFer1HCH) and light chain (GmmFer2LCH) transcripts are expressed ubiquitously, suggesting a more general role for these proteins in iron transport and storage. Protein domain predictions for each IBP suggest both the conservation and loss of several motifs present in their vertebrate homologues. In concert with many other described insect transferrins (Tfs), putative secreted GmmTsf1 maintains 3 of the 5 residues necessary for iron-binding in the N-terminal lobe, but exhibits a loss of this iron-binding ability in the C-terminal lobe as well as a loss of large sequence blocks. Both putative GmmFer1HCH and GmmFer2LCH proteins have signal peptides, similar to other insect ferritins. GmmFer2LCH has lost the 5'UTR iron-responsive element (IRE) and, thus, translation is no longer regulated by cellular iron levels. On the other hand, GmmFer1HCH maintains both the conserved ferroxidase center and the 5'UTR IRE; however, transcript variants suggest a more extensive regulatory mechanism for this subunit.
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