ArticleCancer cell2006
A common signaling cascade may underlie "addiction" to the Src, BCR-ABL, and EGF receptor oncogenes.
Article in Cancer cell, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 119 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
119 citing papers in PubMed, 230 citations in OpenAlex.
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- Study of Strawberry Notch homolog 1 and 2 expression in human glioblastoma.Journal of neuro-oncology · 2023Article
- An oncogene addiction phosphorylation signature and its derived scores inform tumor responsiveness to targeted therapies.Cellular and molecular life sciences : CMLS · 2022Article
- Cinobufagin Exerts Anticancer Activity in Oral Squamous Cell Carcinoma Cells through Downregulation of ANO1.International journal of molecular sciences · 2021Article
- Gelatin methacrylate hydrogels culture model for glioblastoma cells enriches for mesenchymal-like state and models interactions with immune cells.Scientific reports · 2021Article
- Therapeutic inhibition of FcγRIIb signaling targets leukemic stem cells in chronic myeloid leukemia.Leukemia · 2020Article
- CRISPR/Cas9-mediated gene deletion efficiently retards the progression of Philadelphia-positive acute lymphoblastic leukemia in a p210 BCR-ABL1Haematologica · 2020Article
- Epidermal growth factor receptor first generation tyrosine-kinase inhibitors.Translational lung cancer research · 2019Review
- TRIM14 Promotes Breast Cancer Cell Proliferation by Inhibiting Apoptosis.Oncology research · 2019Article
- Targeting TAZ-Driven Human Breast Cancer by Inhibiting a SKP2-p27 Signaling Axis.Molecular cancer research : MCR · 2019Article
- Hyperactivation of ERK by multiple mechanisms is toxic to RTK-RAS mutation-driven lung adenocarcinoma cells.eLife · 2018Article
- Oncodriver inhibition and CD4Oncotarget · 2018Article
- The impact of non-genetic heterogeneity on cancer cell death.Critical reviews in biochemistry and molecular biology · 2018Review
- Cell death-based treatment of lung adenocarcinoma.Cell death & disease · 2018Review
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- Future Clinical Trials: Genetically Driven Trials.Surgical oncology clinics of North America · 2017Review
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- Determining EGFR-TKI sensitivity of G719X and other uncommon EGFR mutations in non-small cell lung cancer: Perplexity and solution (Review).Oncology reports · 2017Review
59 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
"Oncogene addiction" describes an unexplained dependency of cancer cells on a particular cellular pathway for survival or proliferation. We report that differential attenuation rates of prosurvival and proapoptotic signals in oncogene-dependent cells contribute to cell death following oncogene inactivation. Src-, BCR-ABL-, and EGF receptor-dependent cells exhibit a similar profile of signal attenuation following oncogene inactivation characterized by rapid diminution of phospho-ERK, -Akt, and -STAT3/5, and a delayed accumulation of the proapoptotic effector phospho-p38 MAPK. These findings implicate a transient imbalance in survival and apoptotic oncogenic outputs in the apoptotic response to oncogene inactivation. Moreover, these observations implicate a common profile of signal attenuation for multiple oncogenes and suggest that "addiction" associated with apoptosis reflects an active rather than a passive process.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.